ACSM1 - acyl-CoA synthetase medium chain family member 1 Gene

Homo sapiens

Also known as BUCS1; MACS1

Gene ID: 116285 | Gene type: protein coding

About ACSM1

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,623,235-20,697,680 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 13 paralogues. Broad expression in prostate (RPKM 1.3), ovary (RPKM 1.3) and 18 other tissues.

Summary

Enables CoA-ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ACSM1 Products(2)

mRNA	Protein	Name
NM_001318890.3	NP_001305819.1	acyl-coenzyme A synthetase ACSM1, mitochondrial
NM_052956.3	NP_443188.2	acyl-coenzyme A synthetase ACSM1, mitochondrial

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables benzoate-CoA ligase activity	IDA IDA: Inferred from direct assay	10434065	GOA
enables decanoate-CoA ligase activity	IDA IDA: Inferred from direct assay	10434065	GOA
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	11470804	GOA
enables medium-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	10434065	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	11470804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSM1 Protein Structure

AMP-binding

AMP-binding_C

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A synthetase ACSM1, mitochondrial

Butyrate CoA ligase

ACSM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACSM1	Q08AH1	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	ACSM1	Q08AH1	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	ACSM1	Q08AH1	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	ACSM1	Q08AH1	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	ACSM1	Q08AH1	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	ACSM1	Q08AH1	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	ACSM1	Q08AH1	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	ACSM1	Q08AH1	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	ACSM1	Q08AH1	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	ACSM1	Q08AH1	MAGEA2	Homo sapiens	P43356	Y2H Prey Pooling	32296183
Intra	ACSM1	Q08AH1	MAGEA2	Homo sapiens	P43356	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Apocrine Carcinoma

Apocrine Carcinoma Of Breast

Apocrine Breast Carcinoma

Apocrine Adenocarcinoma

Apocrine Carcinoma	Apocrine Gland Carcinoma
Carcinoma Of The Apocrine Gland	Carcinoma Of Apocrine Gland

Acute Hemorrhagic Leukoencephalitis

Ahl	Acute Haemorrhagic Leucoencephalitis Of Weston Hurst
Leukoencephalitis, Acute Hemorrhagic	Acute Hemorrhagic Encephalomyelitis
Acute Necrotizing Hemorrhagic Leukoencephalitis	Weston-Hurst Syndrome
Ahle	Acute Haemorrhagic Leucoencephalitis
Hurst Disease	Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal
Postimmunization Or Postvaccinal Leukoencephalopathy

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome	Abdominal Obesity Metabolic Syndrome
Metabolic Syndrome X	Aoms2
Aoms1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00205	ACSM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACSM1	VGNC	VGNC:50046
Mus musculus	ACSM1	MGD	MGI:2152200
Rattus norvegicus	ACSM1	RGD	RGD:1306813
Macaca mulatta	ACSM1	VGNC	VGNC:69456

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