Slc6a9 - solute carrier family 6 member 9 Gene

Rattus norvegicus

Also known as Glyt1; GLYT-1; GLYT-1b

Gene ID: 116509 | Gene type: protein coding

About Slc6a9

Primary_assembly 5: 131,374,542-131,408,728 forward strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 206 orthologues, 20 paralogues and is associated with 7 phenotypes. Biased expression in Brain (RPKM 173.1), Liver (RPKM 15.1) and 8 other tissues.

Summary

Enables glycine transmembrane transporter activity. Involved in glycine import across plasma membrane. Located in dense core granule; endosome; and plasma membrane. Is active in hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density. Is integral component of postsynaptic membrane; integral component of presynaptic membrane; and integral component of synaptic vesicle membrane. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a9 Products(1)

mRNA	Protein	Name
NM_053818.3	NP_446270.1	sodium- and chloride-dependent glycine transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12091465	RGD
enables glycine:sodium symporter activity	IDA IDA: Inferred from direct assay	1534013	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16181645	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycine import across plasma membrane	IDA IDA: Inferred from direct assay	12091465	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in asymmetric synapse	IDA IDA: Inferred from direct assay	15749988	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	12091465	RGD
located in endosome	IDA IDA: Inferred from direct assay	12091465	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	15749988	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	15749988	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12091465	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	15749988	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	15749988	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	15749988	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	24036061	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a9 Protein Structure

SLC6sbd_GlyT1

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638 a.a.

Protein Preferred Names

Protein Names

sodium- and chloride-dependent glycine transporter 1

glycine transporter 1

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Slc6a9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc6a9	P28572	Dlg4	Rattus norvegicus	P31016	Far-WB	16271045

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13320	SLC6A9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13321	Slc6a9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13322	Slc6a9 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a9	NCBI	NCBI:6536

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