Dlg4 - discs large MAGUK scaffold protein 4 Gene

Rattus norvegicus

Also known as Dlgh4; PSD95; Sap90

Gene ID: 29495 | Gene type: protein coding

About Dlg4

Summary

Enables several functions, including PDZ domain binding activity; Enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic density. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane. Colocalizes with postsynaptic membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Dlg4 Products(1)

mRNA	Protein	Name
NM_019621.2	NP_062567.1	disks large homolog 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	23041629	RGD
enables P2Y1 nucleotide receptor binding	IPI IPI: Inferred from physical interaction	20847060	RGD
enables PDZ domain binding	IMP IMP: Inferred from mutant phenotype	25424568	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	10644767	RGD
enables acetylcholine receptor binding	IDA IDA: Inferred from direct assay	22593058	RGD
enables beta-1 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	11526121	RGD
enables beta-2 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	20395454	RGD
enables frizzled binding	IPI IPI: Inferred from physical interaction	25424568	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	20847060	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	10414981	RGD
enables kinesin binding	IPI IPI: Inferred from physical interaction	12097473	RGD
enables neuroligin family protein binding	IPI IPI: Inferred from physical interaction	11368788	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1127911	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20220006	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	20410104	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11178875	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10939335	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	9808460	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	21525273	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	21525273	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21525273	RGD
involved in NMDA selective glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	12930820	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	14597197	RGD
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21525273	RGD
involved in dendritic spine organization	IMP IMP: Inferred from mutant phenotype	26679993	RGD
involved in negative regulation of receptor internalization	IDA IDA: Inferred from direct assay	11526121	RGD
involved in positive regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	19596852	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	20531396	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	25424568	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	12930820	RGD
involved in positive regulation of neuron projection arborization	IGI IGI: Inferred from genetic interaction	25424568	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	26738857	RGD
involved in positive regulation of synaptic transmission	IDA IDA: Inferred from direct assay	12930820	RGD
involved in protein localization to synapse	IMP IMP: Inferred from mutant phenotype	12097487	RGD
involved in receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	21525273	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	12930820	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	19596852	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	26595655	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11931740	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	1419001	RGD
located in dendritic branch	IDA IDA: Inferred from direct assay	20802490	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	26679993	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19730411	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20357126	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21525273	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	19109503	RGD
located in membrane	IDA IDA: Inferred from direct assay	20089912	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	20847060	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	1419001	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	20357126	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11483650	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	20802490	RGD
located in synapse	IDA IDA: Inferred from direct assay	11483650	RGD
located in synapse	IMP IMP: Inferred from mutant phenotype	27307232	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	10414981	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	20089912	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 4

PSD-95	SAP-90
discs, large homolog 4	postsynaptic density protein 95
synapse-associated protein 90	synapse-associated protein SAP90

Dlg4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dlg4	P31016	Vangl1	Mus musculus	Q80Z96	Anti Tag CoIP	23567299
Cross	Dlg4	P31016	Vangl1	Mus musculus	Q80Z96	Pull Down	23567299
Cross	Dlg4	P31016	Vangl2	Mus musculus	Q91ZD4	Pull Down	23567299
Cross	Dlg4	P31016	Vangl2	Mus musculus	Q91ZD4	Anti Tag CoIP	23567299
Cross	Dlg4	P31016	GRIN2B	Homo sapiens	Q13224	FPS	11937501
Cross	Dlg4	P31016	Src	Mus musculus	P05480	Pull Down	16990796
Cross	Dlg4	P31016	Src	Mus musculus	P05480	Anti Bait CoIP	16990796
Cross	Dlg4	P31016	DLG1	Homo sapiens	Q12959-2	Anti Tag CoIP	16332687
Cross	Dlg4	P31016	DLG1	Homo sapiens	Q12959-2	Pull Down	16332687
Cross	Dlg4	P31016	DLG1	Homo sapiens	Q12959-2	Anti Bait CoIP	16332687
Intra	Dlg4	P31016	Gria1	Rattus norvegicus	P19490	Anti Bait CoIP	29222408
Intra	Dlg4	P31016	Gria1	Rattus norvegicus	P19490	IF	29222408
Intra	Dlg4	P31016	Dlg1	Rattus norvegicus	Q62696	Anti Bait CoIP	16332687
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Anti Bait CoIP	7569905
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Anti Bait CoIP	10341223
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Filter Binding	8601796
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Anti Bait CoIP	16990796
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Y2H	7569905
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Y2H	8601796
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Competition Binding	9786987
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Anti Bait CoIP	23567299
Intra	Dlg4	P31016	Grin2b	Rattus norvegicus	Q00960	Pull Down	7569905
Intra	Dlg4	P31016	Grin2a	Rattus norvegicus	Q00959	Pull Down	11222640
Intra	Dlg4	P31016	Grin2a	Rattus norvegicus	Q00959	Y2H	7569905
Intra	Dlg4	P31016	Grin2a	Rattus norvegicus	Q00959	Y2H Array	10336672
Cross	Dlg4	P31016	KCNA4	Homo sapiens	P22459	ELISA	11937501
Cross	Dlg4	P31016	KCNA4	Homo sapiens	P22459	Pull Down	9786987
Cross	Dlg4	P31016	KCNA4	Homo sapiens	P22459	FPS	11937501
Intra	Dlg4	P31016	Map1a	Rattus norvegicus	P34926	Filter Binding	9786987
Intra	Dlg4	P31016	Map1a	Rattus norvegicus	P34926	Peptide Array	17220895
Intra	Dlg4	P31016	Map1a	Rattus norvegicus	P34926	Pull Down	17220895
Intra	Dlg4	P31016	Map1a	Rattus norvegicus	P34926	NMR	17220895
Intra	Dlg4	P31016	Map1a	Rattus norvegicus	P34926	Far-WB	9786987
Intra	Dlg4	P31016	Apc	Rattus norvegicus	P70478	Competition Binding	9786987
Intra	Dlg4	P31016	Wipf1	Rattus norvegicus	Q6IN36	Pull Down	16990791
Cross	Dlg4	P31016	GRIN2A	Homo sapiens	Q12879	FPS	11937501
Intra	Dlg4	P31016	Tamalin	Rattus norvegicus	Q8R4T5	Anti Bait CoIP	12586822
Intra	Dlg4	P31016	Tamalin	Rattus norvegicus	Q8R4T5	Pull Down	12586822
Intra	Dlg4	P31016	Gucy1a2	Rattus norvegicus	Q9WVI4	Pull Down	11572861
Intra	Dlg4	P31016	Sstr4	Rattus norvegicus	P30937	Anti Tag CoIP	17950729
Intra	Dlg4	P31016	Sstr4	Rattus norvegicus	P30937	Anti Bait CoIP	17950729
Intra	Dlg4	P31016	Sstr4	Rattus norvegicus	P30937	IF	17950729
Intra	Dlg4	P31016	Lrrc7	Rattus norvegicus	P70587	Anti Bait CoIP	12390249
Intra	Dlg4	P31016	Pten	Rattus norvegicus	O54857	Anti Bait CoIP	20628354
Intra	Dlg4	P31016	Pten	Rattus norvegicus	O54857	Density Sedimentation	20628354
Intra	Dlg4	P31016	Dlgap1	Rattus norvegicus	P97836	Protein Array	9115257
Intra	Dlg4	P31016	Dlgap1	Rattus norvegicus	P97836	Imaging	9115257
Intra	Dlg4	P31016	Dlgap1	Rattus norvegicus	P97836	Anti Bait CoIP	11178875
Intra	Dlg4	P31016	Shank1	Rattus norvegicus	Q9WV48	Anti Bait CoIP	11178875
Intra	Dlg4	P31016	Slc6a9	Rattus norvegicus	P28572	Anti Bait CoIP	16271045
Intra	Dlg4	P31016	Slc6a9	Rattus norvegicus	P28572-2	Anti Bait CoIP	16271045
Intra	Dlg4	P31016	Slc6a9	Rattus norvegicus	P28572-2	Pull Down	16271045
Intra	Dlg4	P31016	Slc6a9	Rattus norvegicus	P28572-2	Y2H	16271045
Intra	Dlg4	P31016	Cacng2	Rattus norvegicus	Q71RJ2	Pull Down	12359873
Intra	Dlg4	P31016	Cnksr2	Rattus norvegicus	Q9Z1T4	Anti Bait CoIP	12390249
Intra	Dlg4	P31016	Cnksr2	Rattus norvegicus	Q9Z1T4	Anti Tag CoIP	12390249
Intra	Dlg4	P31016	Cnksr2	Rattus norvegicus	Q9Z1T4	IF	12390249
Intra	Dlg4	P31016	Dgkz	Rattus norvegicus	O08560	Anti Bait CoIP	19229292
Intra	Dlg4	P31016	Dgkz	Rattus norvegicus	O08560	Y2H	19229292
Intra	Dlg4	P31016	Dgkz	Rattus norvegicus	O08560	IF	19229292
Intra	Dlg4	P31016	Lrfn2	Rattus norvegicus	Q460M5	IF	16495444
Intra	Dlg4	P31016	Grin1	Rattus norvegicus	P35439	Anti Bait CoIP	23567299
Intra	Dlg4	P31016	Grin1	Rattus norvegicus	P35439	Anti Bait CoIP	20628354
Intra	Dlg4	P31016	Grin1	Rattus norvegicus	P35439	Density Sedimentation	20628354
Cross	Dlg4	P31016	CRIPT	Homo sapiens	Q9P021	ELISA	11937501
Cross	Dlg4	P31016	ADRB1	Homo sapiens	P08588	Peptide Array	16316992
Cross	Dlg4	P31016	ADRB1	Homo sapiens	P08588	Far-WB	16533813

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Dlg4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71010	PSD95 Protein, Rat (His)	NP_062567 (M1-L724)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03799	DLG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg4	NCBI	NCBI:1742

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