Mapk1 - mitogen activated protein kinase 1 Gene

Rattus norvegicus

Also known as ERT1; Erk2; ERK-2; p42-MAPK

Gene ID: 116590 | Gene type: protein coding

About Mapk1

Primary_assembly 11: 83,957,813-84,023,616 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 214 orthologues, 21 paralogues and is associated with 82 phenotypes. Biased expression in Brain (RPKM 291.5), Adrenal (RPKM 15.7) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; decidualization; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products(1)

mRNA	Protein	Name
NM_053842.2	NP_446294.1	mitogen-activated protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15027896	RGD
enables MAP kinase activity	IDA IDA: Inferred from direct assay	7889942	RGD
enables MAP kinase activity	IMP IMP: Inferred from mutant phenotype	16955078	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	26950759	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	12049732	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12944431	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16943189	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	7768935	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	17310240	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	8223435	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	8246947	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	9235900	RGD
involved in cellular response to methionine	IEP IEP: Inferred from expression pattern	22676582	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	8246947	RGD
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	11875501	RGD
involved in cellular response to toxic substance	IDA IDA: Inferred from direct assay	12487375	RGD
involved in decidualization	IDA IDA: Inferred from direct assay	21248290	RGD
involved in diadenosine tetraphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	22521590	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12072413	RGD
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7768935	RGD
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	16955078	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	26884868	RGD
involved in positive regulation of cell migration	IEP IEP: Inferred from expression pattern	15917991	RGD
involved in positive regulation of cell population proliferation	IEP IEP: Inferred from expression pattern	15583728	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	15027896	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12944431	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19524539	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	21790671	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19457111	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15893655	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	11751611	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	11679970	RGD
involved in response to nicotine	IGI IGI: Inferred from genetic interaction	11404397	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	22265242	RGD
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17651772	RGD
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	11356865	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	9714150	RGD
located in caveola	IDA IDA: Inferred from direct assay	24567387	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	24567387	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	9714150	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	7889942	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9714150	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	24567387	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	7478291	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15781236	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk1 Protein Structure

STKc_ERK1_2_like

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 1

MAP kinase 1	MAP kinase 2
MAPK 1	MAPK 2
extracellular-signal-regulated kinase 2	mitogen-activated protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10406	Talmapimod	Inhibitor	98.97%	Phase 2
HY-10406A	Talmapimod hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13285	Ki16425	Antagonist	98.11%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-P2456	MBP MAPK Substrate		99.71%	Unkown
HY-N2232	N-Feruloyloctopamine	Inhibitor	99.91%	Unkown
HY-149921	Antiangiogenic agent 3		/	Unkown
HY-152087	DCZ19931	Inhibitor	/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-N3487	Isodorsmanin A		/	Unkown
HY-P0141	Akt/SKG Substrate Peptide		/	Unkown
HY-P0141A	Akt/SKG Substrate Peptide TFA		/	Unkown
HY-RS08092	MAPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08093	Mapk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08094	Mapk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk1	NCBI	NCBI:5594

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