Csf2 - colony stimulating factor 2 Gene

Rattus norvegicus

Also known as Gmcsf; Gm-csf

Gene ID: 116630 | Gene type: protein coding

About Csf2

Summary

Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; macrophage activation; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Csf2 Products(1)

mRNA	Protein	Name
NM_053852.1	NP_446304.1	granulocyte-macrophage colony-stimulating factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	8535150	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18387647	RGD
involved in dendritic cell differentiation	IDA IDA: Inferred from direct assay	8535150	RGD
involved in epithelial fluid transport	IDA IDA: Inferred from direct assay	14504066	RGD
involved in histamine secretion	IDA IDA: Inferred from direct assay	9685678	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	8304053	RGD
involved in regulation of circadian sleep/wake cycle, sleep	IMP IMP: Inferred from mutant phenotype	12047622	RGD
involved in response to fluid shear stress	IEP IEP: Inferred from expression pattern	15010288	RGD
involved in response to silicon dioxide	IEP IEP: Inferred from expression pattern	21505002	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	16673407	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	21442011	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

granulocyte-macrophage colony-stimulating factor

CSF	colony stimulating factor 2 (granulocyte-macrophage)
colony-stimulating factor

Recombinant Csf2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7094	GM-CSF Protein, Rat (CHO)	P48750 (A18-K144)	≥95%
HY-P72629	GM-CSF Protein, Rat (HEK293, His)	P48750 (A18-K144)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99207	Lenzilumab		/	Phase 3
HY-P99307	Namilumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7038A	Phytohemagglutinin P	Activator	/	Unkown
HY-RS03231	CSF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03232	CSF2RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03233	CSF2RB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990975	Birinkibart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csf2	NCBI	NCBI:1437
Canis familiaris	Csf2	NCBI	NCBI:403923
Macaca fascicularis	Csf2	NCBI	NCBI:102118747
Mus musculus	Csf2	NCBI	NCBI:12981
Susscrofa domestica	Csf2	NCBI
Macaca mulatta	Csf2	NCBI	NCBI:574371

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