2. Gene
  3. Csf2 - colony stimulating factor 2 (granulocyte-macrophage) Gene

Csf2 - colony stimulating factor 2 (granulocyte-macrophage) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CSF; Csfgm; GMCSF; Gm-CSf; MGI-IGM

Gene ID: 12981 | Gene type: protein coding

About Csf2

Summary

Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; labyrinthine zone; liver; and lung. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Csf2 Products(1)

mRNA Protein Name
NM_009969.4 NP_034099.2 granulocyte-macrophage colony-stimulating factor precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine activity IDA
IDA: Inferred from direct assay
1350248 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
19228596 MGI
acts upstream of or within monocyte differentiation IDA
IDA: Inferred from direct assay
19109256 MGI
acts upstream of or within myeloid dendritic cell differentiation IDA
IDA: Inferred from direct assay
12021780 MGI
acts upstream of or within neutrophil differentiation IDA
IDA: Inferred from direct assay
19109256 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10678181 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
9697835 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19228596 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

granulocyte-macrophage colony-stimulating factor

colony-stimulating factor

granulocyte-macrophage colony stimulating factor 2

put. GM-CSF

Recombinant Csf2 Proteins

Cat. No. Product Name Accession Purity
HY-P7069 GM-CSF Protein, Mouse (CHO) Q14AD9 (A18-K141) ≥95%
HY-P7361 GM-CSF Protein, Mouse Q14AD9 (A18-K141) ≥95%
HY-P70623 GM-CSF Protein, Mouse (HEK293, His) P01587 (A18-K141) ≥95%
HY-P73082 GM-CSF Protein, Mouse (HEK293, Fc) P01587 (A18-K141) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99207 Lenzilumab 99.64% Phase 3
HY-P99307 Namilumab Inhibitor 99.47% Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N7038A Phytohemagglutinin P Activator / Unkown
HY-RS03231 CSF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03232 CSF2RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03233 CSF2RB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990094 Trabikibart 99.17% Unkown
HY-P990975 Birinkibart / Unkown
HY-P990381 Anti-CSF2/GM-CSF Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf2 NCBI NCBI:1437
Canis familiaris Csf2 NCBI NCBI:403923
Macaca fascicularis Csf2 NCBI NCBI:102118747
Susscrofa domestica Csf2 NCBI
Rattus norvegicus Csf2 NCBI NCBI:116630
Macaca mulatta Csf2 NCBI NCBI:574371