Abcd1 - ATP-binding cassette, sub-family D (ALD), member 1 Gene

Mus musculus

Also known as Ald; ALDP; Aldgh

Gene ID: 11666 | Gene type: protein coding

About Abcd1

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in the human gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]

Abcd1 Products(1)

mRNA	Protein	Name
NM_007435.2	NP_031461.1	ATP-binding cassette sub-family D member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10551832	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	10196381	MGI
involved in fatty acid elongation	IMP IMP: Inferred from mutant phenotype	26108493	MGI
involved in fatty acid homeostasis	IMP IMP: Inferred from mutant phenotype	9418970	MGI
involved in myelin maintenance	IMP IMP: Inferred from mutant phenotype	11875044	MGI
involved in negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	18723473	MGI
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	18723473	MGI
involved in neuron projection maintenance	IMP IMP: Inferred from mutant phenotype	11875044	MGI
involved in positive regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	18723473	MGI
involved in positive regulation of unsaturated fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	18854420	MGI
involved in regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	18344354	MGI
involved in regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	9126326	MGI
involved in regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	25583114	MGI
involved in regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	23604518	MGI
involved in sterol homeostasis	IMP IMP: Inferred from mutant phenotype	16213491	MGI
involved in very long-chain fatty acid catabolic process	IMP IMP: Inferred from mutant phenotype	18723473	MGI
involved in very long-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	15489218	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	14561759	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family D member 1

X-linked adrenoleukodystrophy (ALD) gene homolog

adrenoleukodystrophy protein

Abcd1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Abcd1	P48410	ABCD1	Homo sapiens	P33897	CoIP	10551832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145272	ELOVL1-IN-3		99.81%	Unkown
HY-RS00068	ABCD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcd1	NCBI	NCBI:215
Rattus norvegicus	Abcd1	NCBI	NCBI:363516

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