ELOVL1-IN-3

Name: ELOVL1-IN-3
Brand: MedChemExpress
SKU: HY-145272
Rating: 4.5 (1 reviews)

Cat. No.: HY-145272 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ELOVL1-IN-3 (Compound 22) is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD)^[1].

For research use only. We do not sell to patients.

ELOVL1-IN-3 Chemical Structure

CAS No. : 2761063-99-2

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2050	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 10800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

ELOVL1^[1]

In Vitro

ELOVL1-IN-3 (100 nM, 48 hours) selectively inhibits ELOVL1-mediated C26:0 LPC synthesis in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ELOVL1-IN-3 (1-32 mg/kg, p.o., once daily, for 3 months) significantly reduced blood C26:0 lysophosphatidylcholine (LPC) levels in ABCD1 knockout C57BL/6 mice^[1].
ELOVL1-IN-3 (10 or 50 mg/kg, p.o., once daily, for 28 days) significantly reduced blood C26:0 lysophosphatidylcholine (LPC) levels in Sprague-Dawley rats^[1].
ELOVL1-IN-3 (6.5 or 50 mg/kg, p.o., once daily, for 14 days) significantly reduced blood C26:0 lysophosphatidylcholine (LPC) levels in cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ATP binding cassette transporter D1 (ABCD1) knockout mouse model (Adrenoleukodystrophy (ALD) disease)^[1]
Dosage:	1, 4, 8, 16, or 32 mg/kg
Administration:	Oral gavage (p.o.), once daily for 3 months
Result:	Significantly reduced blood C26:0 LPC levels (8 mg/kg or higher brought levels near wild-type).

Animal Model:	Sprague-Dawley rats
Dosage:	10 or 50 mg/kg
Administration:	Oral gavage (p.o.), once daily for 28 days
Result:	Reduced blood C26:0 LPC levels by 78% and 79%, respectively.

Animal Model:	Cynomolgus monkey
Dosage:	6.5 or 50 mg/kg
Administration:	Oral gavage (p.o.), once daily for 14 days
Result:	Reduced blood C26:0 LPC levels by 47% and 65%, respectively.

Molecular Weight

377.44

Formula

C₂₁H₂₃N₅O₂

CAS No.

2761063-99-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

[C@@H]1(C2=CC=CC=C2)OCCN(C3=CC(O[C@@H]4C[C@H](N5C=CC=N5)C4)=NC=N3)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (264.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6494 mL	13.2471 mL	26.4943 mL
5 mM	0.5299 mL	2.6494 mL	5.2989 mL
10 mM	0.2649 mL	1.3247 mL	2.6494 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (257 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Boyd MJ, et al. Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1. J Med Chem. 2021;64(24):17777-17794. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6494 mL	13.2471 mL	26.4943 mL	66.2357 mL
	5 mM	0.5299 mL	2.6494 mL	5.2989 mL	13.2471 mL
	10 mM	0.2649 mL	1.3247 mL	2.6494 mL	6.6236 mL
	15 mM	0.1766 mL	0.8831 mL	1.7663 mL	4.4157 mL
	20 mM	0.1325 mL	0.6624 mL	1.3247 mL	3.3118 mL
	25 mM	0.1060 mL	0.5299 mL	1.0598 mL	2.6494 mL
	30 mM	0.0883 mL	0.4416 mL	0.8831 mL	2.2079 mL
	40 mM	0.0662 mL	0.3312 mL	0.6624 mL	1.6559 mL
	50 mM	0.0530 mL	0.2649 mL	0.5299 mL	1.3247 mL
	60 mM	0.0442 mL	0.2208 mL	0.4416 mL	1.1039 mL
	80 mM	0.0331 mL	0.1656 mL	0.3312 mL	0.8279 mL
	100 mM	0.0265 mL	0.1325 mL	0.2649 mL	0.6624 mL

ELOVL1-IN-3 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELOVL1-IN-32761063-99-2ELOVLElongation of Very Long-chain Fatty AcidsoralELOVL1adrenoleukodystrophyALDABCD1 knockout mouse modelInhibitorinhibitorinhibit

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Complete Stock Solution Preparation Table

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