F2rl1 - F2R like trypsin receptor 1 Gene

Rattus norvegicus

Also known as Par2; Par-2

Gene ID: 116677 | Gene type: protein coding

About F2rl1

Primary_assembly 2: 26,772,278-26,785,226 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 307 orthologues, 14 paralogues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 28.2), Heart (RPKM 22.9) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in positive regulation of glomerular filtration. Acts upstream of or within with a positive effect on vasodilation. Predicted to be located in early endosome; plasma membrane; and pseudopodium. Predicted to be integral component of plasma membrane. Biomarker of lung disease. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

F2rl1 Products(1)

mRNA	Protein	Name
NM_053897.3	NP_446349.1	proteinase-activated receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17693410	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of glomerular filtration	IDA IDA: Inferred from direct assay	12644441	RGD
acts upstream of or within positive effect vasodilation	IDA IDA: Inferred from direct assay	11884377	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	12644441	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl1 Protein Structure

7tm_GPCRs

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 2

Proteinase-activated receptor-2, G protein-coupled receptor 11	coagulation factor II (thrombin) receptor-like 1
coagulation factor II receptor-like 1	thrombin receptor-like 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04634	F2RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04635	F2rl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04636	F2rl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2rl1	NCBI	NCBI:2150

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