F2RL1 - F2R like trypsin receptor 1 Gene

Homo sapiens

Also known as PAR2; GPR11

Gene ID: 2150 | Gene type: protein coding

About F2RL1

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,819,030-76,835,315 (from NCBI)

This gene has 2 transcripts (splice variants), 307 orthologues and 16 paralogues. Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

F2RL1 Products(1)

mRNA	Protein	Name
NM_005242.6	NP_005233.4	proteinase-activated receptor 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	18622013	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	18434511	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10725339	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28445455	GOA
involved in cell-cell junction maintenance	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	18453611	GOA
involved in establishment of endothelial barrier	IDA IDA: Inferred from direct assay	20826780	GOA
involved in leukocyte migration	IDA IDA: Inferred from direct assay	15155775	GOA
involved in mature conventional dendritic cell differentiation	IDA IDA: Inferred from direct assay	16478888	GOA
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	19781631	GOA
involved in negative regulation of chemokine production	IDA IDA: Inferred from direct assay	19865078	GOA
involved in negative regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	19781631	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10725339	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23202369	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	11413129	GOA
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20826780	GOA
involved in positive regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	17500066	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11413129	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19494303	GOA
involved in positive regulation of cytokine production involved in immune response	IDA IDA: Inferred from direct assay	11441110	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10725339	GOA
involved in positive regulation of eosinophil degranulation	IDA IDA: Inferred from direct assay	11714832	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18453611	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	11447194	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	15155775	GOA
involved in positive regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	17991872	GOA
involved in positive regulation of neutrophil mediated killing of gram-negative bacterium	IDA IDA: Inferred from direct assay	21501162	GOA
involved in positive regulation of phagocytosis, engulfment	IDA IDA: Inferred from direct assay	21501162	GOA
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	17991872	GOA
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	11714832	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	19865078	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	18622013	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16410250	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	16410250	GOA
involved in regulation of blood coagulation	IDA IDA: Inferred from direct assay	17848177	GOA
involved in regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18453611	GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	21501162	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	22547407	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17848177	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2RL1 Protein Structure

7tm_1

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 2

G-protein coupled receptor 11	coagulation factor II (thrombin) receptor-like 1
protease-activated receptor 2	thrombin receptor-like 1

F2RL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	F2RL1	P55085	EPR-1	Homo sapiens	Q14868	Anti Bait CoIP	20826780
Intra	F2RL1	P55085	CBL	Homo sapiens	P22681	Anti Bait CoIP	15708858
Intra	F2RL1	P55085	CBL	Homo sapiens	P22681	Confocal	15708858
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Y2H	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Confocal	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	16410250
Intra	F2RL1	P55085	COPS5	Homo sapiens	Q92905	Pull Down	16410250
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Anti Tag CoIP	17693410
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Y2H	17693410
Intra	F2RL1	P55085	TMED2	Homo sapiens	Q15363	Pull Down	17693410

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pancreatitis

Mumps Pancreatitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Alzheimer Disease 12

Ad12	Alzheimer'S Disease 12
Alzheimer Disease, Familial, 12	Alzheimer Disease Familial 12

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Granulomatous Orchitis

Non-Specific Granulomatous Orchitis

Vernal Keratoconjunctivitis

Vkc	Spring Catarrh
Keratoconjunctivitis Vernal	Keratoconjunctivitis, Vernal

Neuroleptic Malignant Syndrome

Rhinitis

Runny Nose

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04634	F2RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04635	F2rl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04636	F2rl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F2RL1	VGNC	VGNC:28684
Canis familiaris	F2RL1	VGNC	VGNC:40549
Mus musculus	F2RL1	MGD	MGI:101910
Macaca mulatta	F2RL1	VGNC	VGNC:110468
Rattus norvegicus	F2RL1	RGD	RGD:620866

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