2. Gene
  3. Amh - anti-Mullerian hormone Gene

Amh - anti-Mullerian hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MIS

Gene ID: 11705 | Gene type: protein coding

About Amh

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. [provided by RefSeq, Jul 2016]

Amh Products(1)

mRNA Protein Name
NM_007445.3 NP_031471.2 muellerian-inhibiting factor precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
9435237 MGI
involved in negative regulation of ovarian follicle development IMP
IMP: Inferred from mutant phenotype
11861535 MGI
involved in ovarian follicle development IMP
IMP: Inferred from mutant phenotype
11606457 MGI
involved in sex determination IMP
IMP: Inferred from mutant phenotype
7954809 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15789443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muellerian-inhibiting factor

Mullerian inhibiting substance

anti-Muellerian hormone

muellerian-inhibiting substance

Recombinant Amh Proteins

Cat. No. Product Name Accession Purity
HY-P71712 Muellerian-inhibiting factor/AMH Protein, Mouse (P.pastoris, His) P27106 (450D-552C) ≥95%
HY-P72077 Muellerian-inhibiting factor/AMH Protein, Mouse P27106 (D450-C552) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00653 AMH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amh NCBI NCBI:268
Macaca fascicularis Amh NCBI NCBI:102144003
Macaca mulatta Amh NCBI NCBI:717539