Khdrbs1 - KH RNA binding domain containing, signal transduction associated 1 Gene

Rattus norvegicus

Also known as P62; Sam68

Gene ID: 117268 | Gene type: protein coding

About Khdrbs1

Summary

Enables SH3 domain binding activity and identical protein binding activity. Involved in cell surface receptor signaling pathway; regulation of alternative mRNA splicing, via spliceosome; and spermatogenesis. Located in cytoplasm; membrane; and nucleus. Part of Grb2-Sos complex. Orthologous to human KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Khdrbs1 Products(1)

mRNA	Protein	Name
NM_130405.2	NP_569089.1	KH domain-containing, RNA-binding, signal transduction-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	12112020	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15345239	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10437794	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12112020	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	10437794	RGD
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15345239	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	10332027	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of Grb2-Sos complex	IDA IDA: Inferred from direct assay	12112020	RGD
located in nucleus	IDA IDA: Inferred from direct assay	10332027	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

KH domain-containing, RNA-binding, signal transduction-associated protein 1

GAP-associated tyrosine phosphoprotein p62	KH domain containing, RNA binding, signal transduction associated 1
KH domain-containing, RNA-binding, signal transduction-associated protein 1-like	p21 Ras GTPase-activating protein-associated p62
p68	src a

Khdrbs1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Khdrbs1	Q91V33	Pik3r1	Rattus norvegicus	Q63787	CoIP	10437794

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07237	KHDRBS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Khdrbs1	NCBI	NCBI:10657

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