Nsmf - NMDA receptor synaptonuclear signaling and neuronal migration factor Gene

Rattus norvegicus

Also known as Jac; Nelf; Jacob

Gene ID: 117536 | Gene type: protein coding

About Nsmf

Summary

Enables calcium-dependent protein binding activity. Involved in several processes, including cellular response to electrical stimulus; postsynapse to nucleus signaling pathway; and regulation of dendrite morphogenesis. Located in several cellular components, including dendrite; euchromatin; and nucleus. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia and hypogonadotropic hypogonadism 9 with or without anosmia. Orthologous to human NSMF (NMDA Receptor synaptonuclear signaling and neuronal migration factor). [provided by Alliance of Genome Resources, Apr 2022]

Nsmf Products(4)

mRNA	Protein	Name
NM_001270626.1	NP_001257555.1	NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 2
NM_001270627.1	NP_001257556.1	NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 3
NM_001270628.1	NP_001257557.1	NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 4
NM_057190.2	NP_476538.2	NMDA receptor synaptonuclear signaling and neuronal migration factor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	18303947	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18303947	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	18303947	RGD
involved in cellular response to electrical stimulus	IDA IDA: Inferred from direct assay	21364755	RGD
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	23452857	RGD
involved in postsynapse to nucleus signaling pathway	IMP IMP: Inferred from mutant phenotype	23452857	RGD
involved in regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18303947	RGD
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18303947	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18303947	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	21364755	RGD
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	18303947	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18303947	RGD
located in euchromatin	IDA IDA: Inferred from direct assay	18303947	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18303947	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23452857	RGD
located in membrane	IDA IDA: Inferred from direct assay	18303947	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	18303947	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	18303947	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	18303947	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	21364755	RGD
located in nucleus	IDA IDA: Inferred from direct assay	18303947	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	21364755	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18303947	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	18303947	RGD
located in synapse	IDA IDA: Inferred from direct assay	18303947	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NMDA receptor synaptonuclear signaling and neuronal migration factor

juxtasynaptic attractor of caldendrin on dendritic boutons protein	nasal embryonic LHRH factor
nasal embryonic luteinizing hormone-releasing hormone factor

Nsmf Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nsmf	Q9EPI6	Ina	Rattus norvegicus	P23565	Pull Down	23452857
Intra	Nsmf	Q9EPI6	Ina	Rattus norvegicus	P23565	Y2H	23452857

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09599	NSMF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nsmf	NCBI	NCBI:26012

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