OLFM3 - olfactomedin 3 Gene

Homo sapiens

Also known as NOE3; NOELIN3; OPTIMEDIN

Gene ID: 118427 | Gene type: protein coding

About OLFM3

Cytogenetic location: 1p21.1 Genomic coordinates (GRCh38): 1:101,802,560-101,996,926 (from NCBI)

This gene has 6 transcripts (splice variants), 203 orthologues and 9 paralogues. Biased expression in brain (RPKM 5.4) and adrenal (RPKM 0.4).

Summary

Predicted to be involved in eye photoreceptor cell development. Predicted to be located in Golgi apparatus; extracellular space; and synapse. Predicted to be part of AMPA glutamate receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

OLFM3 Products(3)

mRNA	Protein	Name
NM_001288821.2	NP_001275750.1	noelin-3 isoform 1 precursor
NM_001288823.2	NP_001275752.1	noelin-3 isoform 3
NM_058170.4	NP_477518.2	noelin-3 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12019210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM3 Protein Structure

Noelin-1

OLF

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

noelin-3

olfactomedin related ER localized protein 3

OLFM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OLFM3	Q96PB7	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	OLFM3	Q96PB7	STUB1	Homo sapiens	Q9UNE7	Y2H Array	31515488
Intra	OLFM3	Q96PB7	STUB1	Homo sapiens	Q9UNE7	Y2H Prey Pooling	25416956
Intra	OLFM3	Q96PB7	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	25416956
Intra	OLFM3	Q96PB7	GLRX3	Homo sapiens	O76003	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Renal Pelvis Carcinoma

Malignant Neoplasm Of Renal Pelvis	Malignant Tumor Of Renal Pelvis
Carcinoma Of Kidney Pelvis	Malignant Renal Pelvis Neoplasm
Renal Pelvis Cancer

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09772	OLFM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OLFM3	VGNC	VGNC:32419
Canis familiaris	OLFM3	VGNC	VGNC:44114
Felis catus	OLFM3	VGNC	VGNC:63960
Mus musculus	OLFM3	MGD	MGI:2387329
Macaca mulatta	OLFM3	VGNC	VGNC:75426
Rattus norvegicus	OLFM3	RGD	RGD:628672

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