Bcl2l10 - Bcl2-like 10 Gene

Mus musculus

Also known as Boo; Diva

Gene ID: 12049 | Gene type: protein coding

About Bcl2l10

Chromosome 9: 75,255,040-75,258,931 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 23 orthologues and is associated with 1 phenotype. Biased expression in ovary adult (RPKM 8.8) and subcutaneous fat pad adult (RPKM .4).

Summary

Enables identical protein binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; and positive regulation of apoptotic process. Located in membrane. Is expressed in early conceptus; epididymis; meninges; and ovary. Human ortholog(s) of this gene implicated in multiple myeloma; myelodysplastic syndrome; and stomach carcinoma. Orthologous to human BCL2L10 (BCL2 like 10). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l10 Products(1)

mRNA	Protein	Name
NM_013479.2	NP_038507.1	bcl-2-like protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	9878060	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17532299	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	9878060	MGI
acts upstream of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9878060	MGI
involved in microtubule organizing center organization	IMP IMP: Inferred from mutant phenotype	27753540	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	9878060	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9878060	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9829980	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	9878060	MGI
located in spindle	IDA IDA: Inferred from direct assay	27753540	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l10 Protein Structure

BCL

0
100
191 a.a.

Protein Preferred Names

Protein Names

bcl-2-like protein 10

anti-apoptotic protein Boo	apoptosis regulator Bcl-B
bcl-2 homolog Diva	bcl2-L-10

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150540	Bcl-2-IN-10		/	Unkown
HY-RS01424	BCL2L10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01425	Bcl2l10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01426	Bcl2l10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl2l10	NCBI	NCBI:10017

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