BCL2L10 - BCL2 like 10 Gene

Homo sapiens

Also known as Boo; Diva; BCL-B; bcl2-L-10

Gene ID: 10017 | Gene type: protein coding

About BCL2L10

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,109,263-52,112,775 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 8 paralogues. Broad expression in skin (RPKM 2.0), kidney (RPKM 1.9) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 Family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with Other members of Bcl-2 protein family including BCL2, BCL2L1/BCL-X(L), and Bax. Overexpression of this gene has been shown to suppress cell Apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating Caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and Caspase 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

BCL2L10 Products(2)

mRNA	Protein	Name
NM_001306168.1	NP_001293097.1	bcl-2-like protein 10 isoform 1
NM_020396.4	NP_065129.1	bcl-2-like protein 10 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	21705382	GOA
enables caspase binding	IPI IPI: Inferred from physical interaction	19255499	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11278245	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	27995898	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11278245	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11278245	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22498477	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	27995898	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11278245	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL2L10 Protein Structure

Bcl-2

0
100
204 a.a.

Protein Preferred Names

Protein Names

bcl-2-like protein 10

BCL2-like 10 (apoptosis facilitator)	anti-apoptotic protein Boo
anti-apoptotic protein NrH	apoptosis regulator Bcl-B
death inducer binding to vBcl-2 and Apaf-1

BCL2L10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BCL2L10	Q9HD36	SAMD4B	Homo sapiens	Q5PRF9	Y2H Prey Pooling	32296183
Intra	BCL2L10	Q9HD36	SAMD4B	Homo sapiens	Q5PRF9	Y2H Array	32296183
Intra	BCL2L10	Q9HD36	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	BCL2L10	Q9HD36	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	BCL2L10	Q9HD36	TMEM200A	Homo sapiens	Q86VY9	Y2H Prey Pooling	32296183
Intra	BCL2L10	Q9HD36	TMEM200A	Homo sapiens	Q86VY9	Y2H Array	32296183
Intra	BCL2L10	Q9HD36	AHCYL1	Homo sapiens	O43865	BN-PAGE	27995898
Intra	BCL2L10	Q9HD36	BMF	Homo sapiens	Q96LC9	Y2H Prey Pooling	32296183
Intra	BCL2L10	Q9HD36	BMF	Homo sapiens	Q96LC9	Y2H Array	32296183
Intra	BCL2L10	Q9HD36	ITPR1	Homo sapiens	Q14643	BN-PAGE	27995898
Intra	BCL2L10	Q9HD36	BAX	Homo sapiens	Q07812	Anti Tag CoIP	23235460
Intra	BCL2L10	Q9HD36	BAX	Homo sapiens	Q07812	Anti Tag CoIP	33961781
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	Y2H Array	32296183
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	SPR	23235460
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	DLS	23235460
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	Anti Tag CoIP	33961781
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	Y2H Prey Pooling	32296183
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	CD	23235460
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	X-Ray Diffraction	23235460
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521	GMS	23235460
Intra	BCL2L10	Q9HD36	BCL2L11	Homo sapiens	O43521-1	Anti Tag CoIP	23235460
Intra	BCL2L10	Q9HD36	BIK	Homo sapiens	Q13323	Anti Tag CoIP	23235460

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150540	Bcl-2-IN-10		/	Unkown
HY-RS01424	BCL2L10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01425	Bcl2l10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01426	Bcl2l10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BCL2L10	VGNC	VGNC:84313
Mus musculus	BCL2L10	MGD	MGI:1330841
Rattus norvegicus	BCL2L10	RGD	RGD:621015

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