Bcl3 - B cell leukemia/lymphoma 3 Gene

Mus musculus

Also known as Bcl-3

Gene ID: 12051 | Gene type: protein coding

About Bcl3

Summary

Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to Other organism; hematopoietic or lymphoid organ development; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]

Bcl3 Products(1)

mRNA	Protein	Name
NM_033601.3	NP_291079.2	B-cell lymphoma 3 protein homolog

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12730195	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16081776	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell apoptotic process	IGI IGI: Inferred from genetic interaction	16832056	MGI
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
acts upstream of or within T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	16081776	MGI
acts upstream of or within antimicrobial humoral response	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	10586052	MGI
acts upstream of or within follicular dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	10586052	MGI
acts upstream of or within germinal center formation	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within marginal zone B cell differentiation	IMP IMP: Inferred from mutant phenotype	9009202	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IGI IGI: Inferred from genetic interaction	16832056	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15465827	MGI
acts upstream of or within positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	15465827	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16081776	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16790793	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	10586052	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	16790793	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

B-cell lymphoma 3 protein homolog

B-cell CLL/lymphoma 3

Bcl3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Bcl3	Q9Z2F6	Cyld	Mus musculus	Q80TQ2	Anti Bait CoIP	16713561
Intra	Bcl3	Q9Z2F6	Cyld	Mus musculus	Q80TQ2	Y2H	16713561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14454	TPh A	Inhibitor	99.81%	Unkown
HY-152177	JS6	Inhibitor	99.67%	Unkown
HY-RS01437	BCL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl3	NCBI	NCBI:602

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