Cyld - CYLD lysine 63 deubiquitinase Gene

Mus musculus

Also known as EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik

Gene ID: 74256 | Gene type: protein coding

About Cyld

Summary

This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating Enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Cyld Products(4)

mRNA	Protein	Name
NM_001128170.2	NP_001121642.1	ubiquitin carboxyl-terminal hydrolase CYLD isoform a
NM_001128171.2	NP_001121643.1	ubiquitin carboxyl-terminal hydrolase CYLD isoform b
NM_001276279.1	NP_001263208.1	ubiquitin carboxyl-terminal hydrolase CYLD isoform c
NM_173369.3	NP_775545.1	ubiquitin carboxyl-terminal hydrolase CYLD isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	16501569	MGI
enables K63-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	16501569	MGI
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	28701375	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16501569	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	16501569	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	16501569	MGI
acts upstream of or within necroptotic process	IGI IGI: Inferred from genetic interaction	21052097	MGI
acts upstream of or within necroptotic process	IMP IMP: Inferred from mutant phenotype	27545878	MGI
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	29291351	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	32424362	MGI
involved in negative regulation of interleukin-18-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	32424362	MGI
involved in negative regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	29291351	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	16501569	MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16501569	MGI
acts upstream of or within positive regulation of protein localization	IDA IDA: Inferred from direct assay	16501569	MGI
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	29291351	MGI
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	29291351	MGI
acts upstream of or within protein deubiquitination	IMP IMP: Inferred from mutant phenotype	22037414	MGI
involved in protein linear deubiquitination	IDA IDA: Inferred from direct assay	28701375	MGI
acts upstream of or within regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	16501569	MGI
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25134987	MGI
involved in regulation of necroptotic process	IDA IDA: Inferred from direct assay	28701375	MGI
acts upstream of or within regulation of protein binding	IDA IDA: Inferred from direct assay	16501569	MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	28701375	MGI
acts upstream of or within ripoptosome assembly involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	22037414	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	25134987	MGI
located in ciliary tip	IDA IDA: Inferred from direct assay	25134987	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase CYLD

cylindromatosis (turban tumor syndrome)	deubiquitinating enzyme CYLD
ubiquitin thioesterase CYLD	ubiquitin thiolesterase CYLD
ubiquitin-specific-processing protease CYLD

Cyld Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cyld	Q80TQ2	Hdac6	Mus musculus	Q9Z2V5	Fluorescence	19893491
Intra	Cyld	Q80TQ2	Tuba1a	Mus musculus	P68369	Fluorescence	19893491
Intra	Cyld	Q80TQ2	Tuba1a	Mus musculus	P68369	Anti Bait CoIP	19893491
Intra	Cyld	Q80TQ2	Itch	Mus musculus	Q8C863	Anti Bait CoIP	22057290
Intra	Cyld	Q80TQ2	Bcl3	Mus musculus	Q9Z2F6	Anti Bait CoIP	19893491
Intra	Cyld	Q80TQ2	Bcl3	Mus musculus	Q9Z2F6	IF	16713561
Intra	Cyld	Q80TQ2	Bcl3	Mus musculus	Q9Z2F6	Y2H	16713561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03433	CYLD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyld	NCBI	NCBI:1540

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