2. Gene
  3. Bdkrb2 - bradykinin receptor, beta 2 Gene

Bdkrb2 - bradykinin receptor, beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B2; B2R; BK2; B(2); BK-2; BK2R; BKR2; BRB2

Gene ID: 12062 | Gene type: protein coding

About Bdkrb2

Chromosome 12: 105,529,485-105,561,496 forward strand.GRCm39:CM001005.3

This gene has 1 transcript (splice variant), 362 orthologues, 9 paralogues and is associated with 27 phenotypes.

Summary

Predicted to enable several functions, including G protein-coupled receptor binding activity; Bradykinin Receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in collecting duct and metanephros. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (Bradykinin Receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

Bdkrb2 Products(1)

mRNA Protein Name
NM_009747.2 NP_033877.3 B2 bradykinin receptor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IGI
IGI: Inferred from genetic interaction
16571598 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
IMP: Inferred from mutant phenotype
16571598 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IGI
IGI: Inferred from genetic interaction
16571598 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
16571598 MGI
acts upstream of or within response to salt stress IGI
IGI: Inferred from genetic interaction
16571598 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
11282893 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B2 bradykinin receptor

BK-2 receptor

kinin B2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01457 BDKRB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01458 Bdkrb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01459 Bdkrb2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bdkrb2 NCBI NCBI:624