Bcl2l11 - BCL2-like 11 (apoptosis facilitator) Gene

Mus musculus

Also known as Bim; Bod; bcl2-L-11; 1500006F24Rik

Gene ID: 12125 | Gene type: protein coding

About Bcl2l11

Chromosome 2: 127,967,958-128,004,467 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 116 orthologues, 2 paralogues and is associated with 84 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues.

Summary

Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 Family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l11 Products(10)

mRNA	Protein	Name
NM_001406060.1	NP_001392989.1	bcl-2-like protein 11 isoform 6
NM_009754.3	NP_033884.1	bcl-2-like protein 11 isoform 3
NM_001291016.1	NP_001277945.1	bcl-2-like protein 11 isoform 5
NM_001406061.1	NP_001392990.1	bcl-2-like protein 11 isoform 7
NM_207680.2	NP_997563.1	bcl-2-like protein 11 isoform 1
NM_207681.2	NP_997564.1	bcl-2-like protein 11 isoform 2
NM_001406059.1	NP_001392988.1	bcl-2-like protein 11 isoform 6
NM_001406057.1	NP_001392986.1	bcl-2-like protein 11 isoform 2
NM_001284410.3	NP_001271339.2	bcl-2-like protein 11 isoform 4
NM_001406058.1	NP_001392987.1	bcl-2-like protein 11 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	16832056	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14561217	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20371704	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	16055554	MGI
acts upstream of T cell apoptotic process	IGI IGI: Inferred from genetic interaction	16832056	MGI
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	17591857	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	16270031	MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of cell cycle	IMP IMP: Inferred from mutant phenotype	17705137	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	17276340	MGI
acts upstream of or within developmental pigmentation	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within ear development	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15967824	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	16282979	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within leukocyte homeostasis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within leukocyte homeostasis	IMP IMP: Inferred from mutant phenotype	15967824	MGI
acts upstream of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16270031	MGI
acts upstream of or within lymphocyte homeostasis	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	11709185	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	16270031	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	17276340	MGI
acts upstream of or within myeloid cell homeostasis	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within positive regulation of T cell apoptotic process	IGI IGI: Inferred from genetic interaction	16832056	MGI
acts upstream of or within positive regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16832056	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17276340	MGI
acts upstream of or within positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17705137	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15967824	MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16270031	MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability involved in apoptotic process	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within regulation of organ growth	IMP IMP: Inferred from mutant phenotype	17276340	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	21159964	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	16270031	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within symbiont-mediated activation of host apoptosis	IDA IDA: Inferred from direct assay	15231831	MGI
acts upstream of or within thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	15967824	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within tube formation	IMP IMP: Inferred from mutant phenotype	17276340	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Bcl-2 family protein complex	IMP IMP: Inferred from mutant phenotype	16645638	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15136728	MGI
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	15136728	MGI
located in membrane	IDA IDA: Inferred from direct assay	15136728	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	15136728	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l11 Protein Structure

Bim_N

Bclx_interact

0
100
196 a.a.

Protein Preferred Names

Protein Names

bcl-2-like protein 11

Bcl2 interacting mediator of cell death

bcl2-interacting mediator of cell death

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153953	Bcl-2-IN-11	Inhibitor	/	Unkown
HY-RS01427	BCL2L11 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01428	Bcl2l11 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01429	Bcl2l11 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl2l11	NCBI	NCBI:10018

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