Bmp4 - bone morphogenetic protein 4 Gene

Mus musculus

Also known as Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1

Gene ID: 12159 | Gene type: protein coding

About Bmp4

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]

Bmp4 Products(2)

mRNA	Protein	Name
NM_001316360.1	NP_001303289.1	bone morphogenetic protein 4 preproprotein
NM_007554.3	NP_031580.2	bone morphogenetic protein 4 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparin binding	IDA IDA: Inferred from direct assay	15381701	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12897139	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	14623234	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	15975920	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of ameloblast differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	14681194	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	16916379	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within anterior/posterior axis specification	IGI IGI: Inferred from genetic interaction	10964473	MGI
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
NOT involved in apoptotic process involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	18924235	MGI
acts upstream of or within blood vessel development	IDA IDA: Inferred from direct assay	17881493	MGI
acts upstream of or within bone development	IDA IDA: Inferred from direct assay	8358941	MGI
acts upstream of or within branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11401393	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	17522159	MGI
acts upstream of or within bud elongation involved in lung branching	IDA IDA: Inferred from direct assay	18367557	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	14681194	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
NOT involved in cardiac jelly development	IMP IMP: Inferred from mutant phenotype	18924235	MGI
involved in cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	21145505	MGI
NOT involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	18924235	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	12421925	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	18028901	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of chondrocyte differentiation	IDA IDA: Inferred from direct assay	17481601	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20059955	MGI
involved in coronary vasculature development	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within cranial suture morphogenesis	IDA IDA: Inferred from direct assay	9477322	MGI
involved in deltoid tuberosity development	IMP IMP: Inferred from mutant phenotype	20059955	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	15218525	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	9268572	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	10964473	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	9664686	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9664686	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	15716346	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IGI IGI: Inferred from genetic interaction	9664686	MGI
acts upstream of or within embryonic skeletal joint morphogenesis	IMP IMP: Inferred from mutant phenotype	9664686	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	16712836	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in endocardial cushion development	IMP IMP: Inferred from mutant phenotype	18924235	MGI
involved in endochondral ossification	IMP IMP: Inferred from mutant phenotype	20059955	MGI
acts upstream of or within endoderm development	IDA IDA: Inferred from direct assay	24835669	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18028901	MGI
NOT involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	18924235	MGI
acts upstream of or within epithelial-mesenchymal cell signaling	IDA IDA: Inferred from direct assay	8104708	MGI
acts upstream of or within epithelium development	IDA IDA: Inferred from direct assay	8898217	MGI
acts upstream of or within erythrocyte differentiation	IDA IDA: Inferred from direct assay	15591122	MGI
NOT involved in eye development	IGI IGI: Inferred from genetic interaction	16154126	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	14681194	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	11784076	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	15289457	MGI
involved in glomerular capillary formation	IMP IMP: Inferred from mutant phenotype	18272846	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	12975322	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	7799920	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	17555714	MGI
involved in kidney development	IGI IGI: Inferred from genetic interaction	16154126	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within lens induction in camera-type eye	IMP IMP: Inferred from mutant phenotype	9851982	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16414041	MGI
acts upstream of or within mammary gland formation	IMP IMP: Inferred from mutant phenotype	17071745	MGI
involved in membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within mesoderm formation	IDA IDA: Inferred from direct assay	7799920	MGI
acts upstream of or within mesodermal cell differentiation	IDA IDA: Inferred from direct assay	7799920	MGI
acts upstream of or within mesodermal cell fate determination	IMP IMP: Inferred from mutant phenotype	7657163	MGI
acts upstream of or within metanephros development	IDA IDA: Inferred from direct assay	12631064	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	12631064	MGI
NOT involved in muscular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	18924235	MGI
involved in negative regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	15634693	MGI
acts upstream of or within negative regulation of branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	21281623	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	17481601	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18028901	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11401393	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	11493558	MGI
acts upstream of or within negative regulation of prostatic bud formation	IDA IDA: Inferred from direct assay	18393306	MGI
acts upstream of or within negative regulation of prostatic bud formation	IMP IMP: Inferred from mutant phenotype	11401393	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9585504	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within neural tube closure	IDA IDA: Inferred from direct assay	19850029	MGI
acts upstream of or within neuron fate commitment	IDA IDA: Inferred from direct assay	17698011	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	17698011	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IDA IDA: Inferred from direct assay	15525533	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	16179481	MGI
acts upstream of or within organ induction	IMP IMP: Inferred from mutant phenotype	9806931	MGI
acts upstream of or within osteoblast differentiation	IDA IDA: Inferred from direct assay	15381701	MGI
involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	21145505	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within pericyte cell differentiation	IDA IDA: Inferred from direct assay	16546160	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	9806931	MGI
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	20059955	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18692041	MGI
involved in positive regulation of branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	17350185	MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	23863481	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24603907	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18692041	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15070745	MGI
involved in positive regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	15525533	MGI
involved in positive regulation of epithelial to mesenchymal transition	IGI IGI: Inferred from genetic interaction	23863481	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19001364	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18622394	MGI
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	21145505	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
involved in positive regulation of odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	29148101	MGI
acts upstream of or within positive regulation of ossification	IDA IDA: Inferred from direct assay	8358941	MGI
acts upstream of positive effect positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	34995814	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18692041	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8104708	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8898217	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18692041	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of prostatic bud formation	IMP IMP: Inferred from mutant phenotype	11401393	MGI
involved in pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	15070745	MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15772937	MGI
acts upstream of or within regulation of cartilage development	IDA IDA: Inferred from direct assay	20501701	MGI
acts upstream of or within regulation of cell differentiation	IGI IGI: Inferred from genetic interaction	15525533	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	10704389	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11436557	MGI
acts upstream of or within regulation of mesodermal cell differentiation	IDA IDA: Inferred from direct assay	17881493	MGI
acts upstream of or within regulation of mesodermal cell differentiation	IGI IGI: Inferred from genetic interaction	17881493	MGI
acts upstream of or within regulation of morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	11401393	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9244299	MGI
acts upstream of or within regulation of smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	17881493	MGI
acts upstream of or within regulation of smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	17881493	MGI
acts upstream of or within regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	15800000	MGI
acts upstream of or within renal system process	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within skeletal system development	IDA IDA: Inferred from direct assay	14654219	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15936012	MGI
acts upstream of or within smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	16546160	MGI
involved in smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	12631064	MGI
acts upstream of or within specification of animal organ position	IMP IMP: Inferred from mutant phenotype	17071745	MGI
involved in specification of segmental identity, mandibular segment	IDA IDA: Inferred from direct assay	11784076	MGI
acts upstream of or within telencephalon regionalization	IDA IDA: Inferred from direct assay	16855091	MGI
acts upstream of or within telencephalon regionalization	IGI IGI: Inferred from genetic interaction	11719201	MGI
involved in tendon cell differentiation	IMP IMP: Inferred from mutant phenotype	20059955	MGI
acts upstream of or within trachea formation	IMP IMP: Inferred from mutant phenotype	18692041	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8898217	MGI
involved in ureter morphogenesis	IMP IMP: Inferred from mutant phenotype	17442697	MGI
acts upstream of or within ureteric bud development	IDA IDA: Inferred from direct assay	12631064	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	12631064	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	17881493	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	8358941	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17481601	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 4

bone morphogenetic protein 2B

Recombinant Bmp4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74379	BMP-4 Protein, Mouse (HEK293, Fc)	P21275 (S293-R408)	≥95%
HY-P700163AF	Animal-Free BMP-4 Protein, Mouse (His)	P21275 (K303-R408)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-16712	LDN-214117	Inhibitor	99.92%	Unkown
HY-18961	PD 407824	Inhibitor	98.34%	Unkown
HY-147372	SJ000063181	Agonist	98.92%	Unkown
HY-P10710	BMP-4	Inhibitor	/	Unkown
HY-RS01539	BMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp4	NCBI	NCBI:652

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