2. Gene
  3. Bmp4 - bone morphogenetic protein 4 Gene

Bmp4 - bone morphogenetic protein 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1

Gene ID: 12159 | Gene type: protein coding

About Bmp4

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]

Bmp4 Products(2)

mRNA Protein Name
NM_001316360.1 NP_001303289.1 bone morphogenetic protein 4 preproprotein
NM_007554.3 NP_031580.2 bone morphogenetic protein 4 preproprotein
Protein Preferred Names Protein Names

bone morphogenetic protein 4

bone morphogenetic protein 2B

Recombinant Bmp4 Proteins

Cat. No. Product Name Accession Purity
HY-P74379 BMP-4 Protein, Mouse (HEK293, Fc) P21275 (S293-R408) ≥95%
HY-P700163AF Animal-Free BMP-4 Protein, Mouse (His) P21275 (K303-R408) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-16712 LDN-214117 Inhibitor 99.92% Unkown
HY-18961 PD 407824 Inhibitor 98.02% Unkown
HY-147372 SJ000063181 Agonist 98.92% Unkown
HY-RS01539 BMP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp4 NCBI NCBI:652