2. Immunology/Inflammation
  3. IFNAR Interleukin Related COX
  4. BMP-4

BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In murine chondrocytes and macrophages, BMP-4 regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 in a dose-dependent manner, effectively suppressing inflammation and alleviating various arthritis symptoms.

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Custom Peptide Synthesis

BMP-4 Chemical Structure

BMP-4 Chemical Structure

CAS No. : 1629625-47-3

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BMP-4 Related Antibodies

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Description

BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In murine chondrocytes and macrophages, BMP-4 regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 in a dose-dependent manner, effectively suppressing inflammation and alleviating various arthritis symptoms[1].

IC50 & Target

IL-6

 

COX-2

 

Molecular Weight

1308.52

Formula

C52H93N25O13S
CAS No.
Sequence

Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His
Sequence Shortening

RKKNPNCRRH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMP-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP-41629625-47-3BMP4BMP 4IFNARInterleukin RelatedCOXInterferon-α/β receptorInterferon-alpha/beta receptor ILCyclooxygenaseInhibitorinhibitorinhibit

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