ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

Homo sapiens

Also known as ABH2

Gene ID: 121642 | Gene type: protein coding

About ALKBH2

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,088,189-109,093,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in ovary (RPKM 6.9), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH2 Products(5)

mRNA	Protein	Name
NM_001001655.3	NP_001001655.1	DNA oxidative demethylase ALKBH2 isoform 1
NM_001145374.2	NP_001138846.1	DNA oxidative demethylase ALKBH2 isoform 1
NM_001145375.2	NP_001138847.1	DNA oxidative demethylase ALKBH2 isoform 1
NM_001205179.2	NP_001192108.1	DNA oxidative demethylase ALKBH2 isoform 2
NM_001205180.2	NP_001192109.1	DNA oxidative demethylase ALKBH2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables broad specificity oxidative DNA demethylase activity	IDA IDA: Inferred from direct assay	12486230	GOA
enables cytosine C-5 DNA demethylase activity	IDA IDA: Inferred from direct assay	18432238	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	18432238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19736315	GOA
enables rDNA binding	IDA IDA: Inferred from direct assay	23972994	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	18432238	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	23972994	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	23972994	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19736315	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH2 Protein Structure

2OG-FeII_Oxy_2

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

DNA oxidative demethylase ALKBH2

2OG-Fe(II) oxy DC1

ALKBH2 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALKBH2	Q6NS38	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ALKBH2	Q6NS38	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ALKBH2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82302	ALKBH2 Antibody (YA2047)	WB	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-168708	AH2-14c		98.01%	Unkown
HY-RS00604	ALKBH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ALKBH2	VGNC	VGNC:25833
Felis catus	ALKBH2	VGNC	VGNC:59750
Rattus norvegicus	ALKBH2	RGD	RGD:1306377
Mus musculus	ALKBH2	MGD	MGI:2141032
Canis familiaris	ALKBH2	VGNC	VGNC:37803

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