C1qa - complement component 1, q subcomponent, alpha polypeptide Gene

Mus musculus

Also known as C1q; Adic

Gene ID: 12259 | Gene type: protein coding

About C1qa

Summary

Involved in several processes, including complement-mediated synapse pruning; microglial cell activation; and nervous system development. Acts upstream of or within complement activation, classical pathway. Located in postsynapse. Is expressed in brain; foot; genitourinary system; and pancreas. Used to study epilepsy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human C1QA (complement C1q A chain). [provided by Alliance of Genome Resources, Apr 2022]

C1qa Products(1)

mRNA	Protein	Name
NM_007572.2	NP_031598.2	complement C1q subcomponent subunit A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22682250	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte activation	IGI IGI: Inferred from genetic interaction	15269255	MGI
acts upstream of or within complement activation, classical pathway	IMP IMP: Inferred from mutant phenotype	11901193	MGI
involved in complement-mediated synapse pruning	IMP IMP: Inferred from mutant phenotype	18083105	MGI
involved in microglial cell activation	IGI IGI: Inferred from genetic interaction	15269255	MGI
involved in neuron remodeling	IMP IMP: Inferred from mutant phenotype	18083105	MGI
involved in synapse organization	IGI IGI: Inferred from genetic interaction	27033548	MGI
involved in synapse pruning	IGI IGI: Inferred from genetic interaction	27033548	MGI
involved in vertebrate eye-specific patterning	IMP IMP: Inferred from mutant phenotype	18083105	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extrinsic component of postsynaptic membrane	IDA IDA: Inferred from direct assay	23946404	MGI
is active in extrinsic component of presynaptic membrane	IDA IDA: Inferred from direct assay	23946404	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23946404	MGI
located in postsynapse	IGI IGI: Inferred from genetic interaction	27033548	MGI
located in synapse	IDA IDA: Inferred from direct assay	18083105	MGI
located in synapse	IGI IGI: Inferred from genetic interaction	18083105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

complement C1q subcomponent subunit A

adiponectin c

Recombinant C1qa Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71718	C1QA Protein, Mouse (P.pastoris, His)	P98086 (E23-A245)	≥95%
HY-P72108	C1QA Protein, Mouse (His-SUMO)	P98086 (E23-A245)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01718	C1QA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	C1qa	NCBI	NCBI:712

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