Calcr - calcitonin receptor Gene

Mus musculus

Also known as Clr; Ct-r

Gene ID: 12311 | Gene type: protein coding

About Calcr

Chromosome 6: 3,685,680-3,764,714 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 218 orthologues, 41 paralogues and is associated with 9 phenotypes. Biased expression in whole brain E14.5 (RPKM 1.5), CNS E18 (RPKM 1.2) and 5 other tissues.

Summary

Enables Calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcr Products(5)

mRNA	Protein	Name
NM_001042725.1	NP_001036190.1	calcitonin receptor isoform 1a precursor
NM_007588.2	NP_031614.2	calcitonin receptor isoform 1b precursor
NM_001355192.1	NP_001342121.1	calcitonin receptor isoform 1a precursor
NM_001377018.1	NP_001363947.1	calcitonin receptor isoform 1b precursor
NM_001042725.1	NP_001036190.1	calcitonin receptor isoform 1a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcitonin receptor activity	IDA IDA: Inferred from direct assay	7988453	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7988453	MGI
acts upstream of or within negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	14970190	MGI
acts upstream of ossification	IMP IMP: Inferred from mutant phenotype	14970190	MGI
acts upstream of or within osteoclast differentiation	IDA IDA: Inferred from direct assay	7664679	MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	9753683	MGI
NOT acts upstream of or within regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	14970190	MGI
acts upstream of or within regulation of mRNA stability	IDA IDA: Inferred from direct assay	9002981	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	12704735	MGI
located in cilium	IDA IDA: Inferred from direct assay	12704735	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Calcr Protein Structure

HRM

7tmB1_calcitonin_R

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

calcitonin receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01832	CALCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01833	Calcr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01834	Calcr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calcr	NCBI	NCBI:799

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