Camk2a - calcium/calmodulin-dependent protein kinase II alpha Gene

Mus musculus

Also known as CaMKII; mKIAA0968

Gene ID: 12322 | Gene type: protein coding

About Camk2a

Chromosome 18: 61,058,690-61,121,224 forward strand.GRCm39:CM001011.3

This gene has 7 transcripts (splice variants), 167 orthologues, 21 paralogues and is associated with 48 phenotypes. Biased expression in cortex adult (RPKM 365.9) and frontal lobe adult (RPKM 31.4).

Summary

Enables Calmodulin binding activity; glutamate receptor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; positive regulation of cardiac muscle cell apoptotic process; and response to ischemia. Located in Schaffer collateral - CA1 synapse; mitochondrion; and postsynaptic density. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/Calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Camk2a Products(5)

mRNA	Protein	Name
NM_009792.3	NP_033922.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 precursor
NM_001286809.1	NP_001273738.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3 precursor
NM_177407.4	NP_803126.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001403312.1	NP_001390241.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001403309.1	NP_001390238.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	15994560	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	15994560	MGI
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	16710293	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10862698	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18480293	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	12660151	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	25297099	MGI
involved in negative regulation of hydrolase activity	IMP IMP: Inferred from mutant phenotype	23502535	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23051746	MGI
involved in peptidyl-threonine autophosphorylation	IMP IMP: Inferred from mutant phenotype	28130356	MGI
acts upstream of or within positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	23051746	MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23051746	MGI
acts upstream of or within protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	12660151	MGI
involved in regulation of endocannabinoid signaling pathway	IMP IMP: Inferred from mutant phenotype	23502535	MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	23051746	MGI
acts upstream of or within regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17610578	MGI
acts upstream of or within regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	12629219	MGI
involved in regulation of synaptic vesicle docking	IDA IDA: Inferred from direct assay	17660813	MGI
involved in regulation of synaptic vesicle docking	IMP IMP: Inferred from mutant phenotype	17660813	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	23051746	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17660813	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	17660813	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	23051746	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in synapse	IDA IDA: Inferred from direct assay	28642476	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Camk2a Protein Structure

STKc_CaMKII

CaMKII_AD

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase type II subunit alpha

CaMK II	alpha-CaMKII
caM kinase II subunit alpha	caMK-II subunit alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-RS01854	CAMK2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01855	Camk2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01856	Camk2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Camk2a	NCBI	NCBI:815

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