CAMK2A - calcium/calmodulin dependent protein kinase II alpha Gene

Homo sapiens

Also known as CAMKA; MRD53; MRT63; CaMKIIalpha; CaMKIINalpha

Gene ID: 815 | Gene type: protein coding

About CAMK2A

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,219,491-150,290,130 (from NCBI)

This gene has 23 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 4 phenotypes. Restricted expression toward brain (RPKM 112.2).

Summary

The product of this gene belongs to the serine/threonine protein kinases family, and to the CA(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

CAMK2A Products(5)

mRNA	Protein	Name
NM_015981.4	NP_057065.2	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1
NM_001369025.2	NP_001355954.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3
NM_171825.3	NP_741960.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363990.1	NP_001350919.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2
NM_001363989.1	NP_001350918.1	calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11972023	GOA
enables calmodulin binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20668654	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	17052756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17052756	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20668654	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	28130356	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	20584908	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	35568036	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	11972023	GOA
involved in dendritic spine development	IMP IMP: Inferred from mutant phenotype	28130356	GOA
involved in peptidyl-threonine autophosphorylation	IMP IMP: Inferred from mutant phenotype	28130356	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17052756	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11972023	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17052756	GOA
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	29100089	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium- and calmodulin-dependent protein kinase complex	IDA IDA: Inferred from direct assay	20668654	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	28130356	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2A Protein Structure

Pkinase

CaMKII_AD

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase type II subunit alpha

CaM kinase II alpha subunit	CaM-kinase II alpha chain
CaMK-II alpha subunit	caM kinase II subunit alpha
caMK-II subunit alpha	calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
calcium/calmodulin-dependent protein kinase II alpha-B subunit	calcium/calmodulin-dependent protein kinase type II alpha chain

CAMK2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Anti Bait CoIP	17353931
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2B	Homo sapiens	Q13554	TAP	27173435
Intra	CAMK2A	Q9UQM7	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	25852190
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Bait CoIP	17353931
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Solution Sedimentation	20668654
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	CAMK2D	Homo sapiens	Q13557	Anti Tag CoIP	25852190
Intra	CAMK2A	Q9UQM7	CAMK2G	Homo sapiens	Q13555	Pull Down	32707033
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	CAMK2A	Q9UQM7	GRIN2B	Homo sapiens	Q13224	Pull Down	19453375
Intra	CAMK2A	Q9UQM7	GRIN2B	Homo sapiens	Q13224	Competition Binding	19453375
Intra	CAMK2A	Q9UQM7	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	CAMK2A	Q9UQM7	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CAMK2A	Q9UQM7	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CAMK2A	Q9UQM7	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	33961781
Intra	CAMK2A	Q9UQM7	MRPL11	Homo sapiens	Q9Y3B7	Validated Y2H	32296183
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Y2H Pooling	32814053
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	PNP	Homo sapiens	P00491	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	CAMK2A	Q9UQM7	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76761	CaMKII alpha/CAMK2A Protein, Human (sf9, GST)	Q9UQM7-1 (M1-H478)	≥95%

Related Diseases

Diseases

Alias

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
Frax Syndrome	Symptomatic Form Of Fragile X Syndrome In Female Carriers
Fragile-X Syndrome	Fraxe Syndrome

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Intellectual Developmental Disorder, Autosomal Recessive 63

MRT63

Mental Retardation, Autosomal Recessive 63

Intellectual Developmental Disorder, Autosomal Dominant 53

MRD53	Mental Retardation, Autosomal Dominant 53
Autosomal Dominant Intellectual Developmental Disorder 53	Autosomal Dominant Mental Retardation 53
Mental Retardation, Autosomal Dominant, Type 53

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autosomal Dominant Non-Syndromic Intellectual Disability

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-RS01854	CAMK2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01855	Camk2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01856	Camk2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CAMK2A	VGNC	VGNC:38680
Macaca mulatta	CAMK2A	VGNC	VGNC:70523
Bos taurus	CAMK2A	VGNC	VGNC:26721
Rattus norvegicus	CAMK2A	RGD	RGD:2261
Felis catus	CAMK2A	VGNC	VGNC:60331
Mus musculus	CAMK2A	MGD	MGI:88256
Others	CAMK2A	NCBI

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