SENP8 - SUMO peptidase family member, NEDD8 specific Gene

Homo sapiens

Also known as DEN1; NEDP1; PRSC2

Gene ID: 123228 | Gene type: protein coding

About SENP8

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,114,258-72,143,692 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in testis (RPKM 2.2), thyroid (RPKM 1.6) and 23 other tissues.

Summary

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

SENP8 Products(5)

mRNA	Protein	Name
NM_001166340.2	NP_001159812.1	sentrin-specific protease 8
NM_001172109.1	NP_001165580.1	sentrin-specific protease 8
NM_001172110.1	NP_001165581.1	sentrin-specific protease 8
NM_001172111.2	NP_001165582.1	sentrin-specific protease 8
NM_145204.4	NP_660205.3	sentrin-specific protease 8

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP8 Protein Structure

Peptidase_C48

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

sentrin-specific protease 8

NEDD8 specific-protease cysteine 2

Recombinant SENP8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71290	SENP8 Protein, Human (His)	Q96LD8 (M1-K212)	≥95%

Related Diseases

Diseases

Alias

St. Louis Encephalitis

Saint Louis Encephalitis	Neuroinvasive St. Louis Encephalitis Virus Infection
Encephalitis, St. Louis	Neuroinvasive Saint Louis Encephalitis Virus Infection
St. Louis Encephalitis Virus Infection	St. Louis Encephalitis Virus Neuroinvasive Disease
St. Louis Viral Disease	Type C Lethargic Encephalitis
Encephalitis Type C

Kunjin Encephalitis

Kyasanur Forest Disease

Kfd	Monkey Fever
Kfd Virus	Kyasanur Hemorrhagic Fever
Monkey Disease	Monkey Diseases
Kfd - [ Kyasanur Forest Disease]	Monkey Sickness

Asymptomatic Dengue

Dengue Hemorrhagic Fever

Severe Dengue	Dengue Haemorrhagic Fever
Dhf	Severe Dengue Haemorrhagic Fever
Severe Dengue Fever	Dengue Shock Syndrome

Panophthalmitis

Dengue Disease

Dengue Fever	Dengue
Df	Dengue Shock Syndrome
Dengue Virus Infection	Breakbone Fever
Classic Dengue	Classical Dengue
Dengue Hemorrhagic Fever	Hemorrhagic Dengue
Philippine Hemorrhagic Fever	Singapore Hemorrhagic Fever
Thai Hemorrhagic Fever	Severe Dengue
Dengue Fever Without Warning Signs	Dengue Haemorrhagic Fever Grade 1
Dengue Haemorrhagic Fever Without Warning Signs	Bangkok Haemorrhagic Fever
Singapore Haemorrhagic Fever	Thailand Haemorrhagic Fever
Southeast Asia Haemorrhagic Fever	Dhf -[Dengue Haemorrhagic Fever]
Dengue Fever With Warning Signs	Dengue Haemorrhagic Fever With Warning Signs
Dengue Haemorrhagic Fever Grade 2	Philippine Haemorrhagic Fever

Dengue Shock Syndrome

Dss

Murray Valley Encephalitis

Australian Encephalitis	Australian X Disease
Encephalitis Australia	Murray River Encephalitis
Australian Arboencephalitis	Australian X Disorder
Mve - [Murray Valley Encephalitis]

Acalculous Cholecystitis

Acute Cholecystitis Without Calculus	Acute Acalculous Cholecystitis
Cholecystitis Without Calculus

Acute Hemorrhagic Encephalitis

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Purulent Endophthalmitis

Periocular Infection	Acute Endophthalmitis
Endophthalmia	Eye Infestation Nos
Intraocular Infection	Eye Infection Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12677	SENP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SENP8	MGD	MGI:1918849
Macaca mulatta	SENP8	VGNC	VGNC:77290
Felis catus	SENP8	VGNC	VGNC:65006
Rattus norvegicus	SENP8	RGD	RGD:1309955
Canis familiaris	SENP8	VGNC	VGNC:46008
Others	SENP8	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.