Casp3 - caspase 3 Gene

Mus musculus

Also known as CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik

Gene ID: 12367 | Gene type: protein coding

About Casp3

Chromosome 8: 47,070,326-47,092,724 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 334 orthologues, 11 paralogues and is associated with 73 phenotypes. Broad expression in CNS E18 (RPKM 54.1), CNS E14 (RPKM 37.8) and 16 other tissues.

Summary

This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through Apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal Apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Casp3 Products(2)

mRNA	Protein	Name
NM_009810.3	NP_033940.1	caspase-3
NM_001284409.1	NP_001271338.1	caspase-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	15231831	MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	12970760	MGI
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	14657025	MGI
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16183742	MGI
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	12124386	MGI
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	17544522	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	12124386	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	12427836	MGI
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	11549719	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17124493	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	11092819	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within anterior neural tube closure	IMP IMP: Inferred from mutant phenotype	21515572	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	9512515	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15068794	MGI
acts upstream of or within epithelial cell apoptotic process	IDA IDA: Inferred from direct assay	17901126	MGI
acts upstream of or within execution phase of apoptosis	IDA IDA: Inferred from direct assay	12124386	MGI
acts upstream of or within execution phase of apoptosis	IGI IGI: Inferred from genetic interaction	16469926	MGI
acts upstream of or within execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	11549719	MGI
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	8934524	MGI
acts upstream of or within fibroblast apoptotic process	IDA IDA: Inferred from direct assay	12847083	MGI
acts upstream of or within fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	16469926	MGI
acts upstream of or within glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11549719	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	16469926	MGI
involved in intrinsic apoptotic signaling pathway in response to osmotic stress	IDA IDA: Inferred from direct assay	21716255	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	15068794	MGI
acts upstream of or within negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	12970760	MGI
acts upstream of or within neuron apoptotic process	IDA IDA: Inferred from direct assay	12427836	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10618441	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10479688	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21716255	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	15231831	MGI
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	33303681	MGI
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	33303681	MGI
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	11092819	MGI
acts upstream of or within response to UV	IGI IGI: Inferred from genetic interaction	16469926	MGI
acts upstream of or within response to wounding	IDA IDA: Inferred from direct assay	14507967	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	11374883	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12477715	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21151119	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21151119	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22358842	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21151119	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	21151119	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp3 Protein Structure

CASc

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

caspase-3

SREBP cleavage activity 1	apopain
caspase 3, apoptosis related cysteine protease	cysteine protease CPP32
protein Yama

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10656	Ac-DEVDD-TPP	Inducer	/	Unkown
HY-RS01952	CASP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01953	Casp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01954	Casp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp3	NCBI	NCBI:836

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