Casp8 - caspase 8 Gene

Mus musculus

Also known as MACH; Mch5; FLICE; CASP-8

Gene ID: 12370 | Gene type: protein coding

About Casp8

Chromosome 1: 58,834,533-58,886,662 forward strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 132 orthologues, 11 paralogues and is associated with 29 phenotypes. Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues.

Summary

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Casp8 Products(3)

mRNA	Protein	Name
NM_001277926.1	NP_001264855.1	caspase-8 isoform 2
NM_001080126.1	NP_001073595.1	caspase-8 isoform 1
NM_009812.2	NP_033942.1	caspase-8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IDA IDA: Inferred from direct assay	9837723	MGI
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	15456877	MGI
enables cysteine-type endopeptidase activity	IGI IGI: Inferred from genetic interaction	21368763	MGI
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	31511692	MGI
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12065591	MGI
enables cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	31827281	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	22037414	MGI
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	22037414	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	11369777	MGI
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	12404118	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11684016	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12011074	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12404118	MGI
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	31748744	MGI
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	16183742	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16183742	MGI
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	24813849	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10588860	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	22089168	MGI
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	31748744	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15322156	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	12404118	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	31748744	MGI
acts upstream of or within hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	15322156	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	15322156	MGI
acts upstream of necroptotic process	IGI IGI: Inferred from genetic interaction	21368763	MGI
acts upstream of or within negative regulation of necroptotic process	IGI IGI: Inferred from genetic interaction	21368763	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	31511692	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	12404118	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9654089	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9654089	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24813849	MGI
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	9837723	MGI
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	9729047	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16183742	MGI
involved in protein processing	IDA IDA: Inferred from direct assay	30361383	MGI
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	32971525	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	30361383	MGI
involved in pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	31748744	MGI
acts upstream of or within regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	15456877	MGI
involved in regulation of cytokine production	IDA IDA: Inferred from direct assay	32971525	MGI
involved in regulation of innate immune response	IDA IDA: Inferred from direct assay	32971525	MGI
acts upstream of or within regulation of thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	15456877	MGI
involved in self proteolysis	IMP IMP: Inferred from mutant phenotype	31511692	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Noc1p-Noc2p complex	IMP IMP: Inferred from mutant phenotype	14657025	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10638761	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12065591	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10638761	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp8 Protein Structure

DED_Caspase_8_r1

CASc

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

caspase-8

Fas-linked ICE-like protease

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153161	CASP8-IN-1	Inhibitor	98.97%	Unkown
HY-P10146	Ac-LETD-CHO	Inhibitor	/	Unkown
HY-RS01965	CASP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01966	Casp8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01967	Casp8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp8	NCBI	NCBI:841

Name
Email *

	Sorry, but the email address you supplied was invalid.