CMKLR1 - chemerin chemokine-like receptor 1 Gene

Homo sapiens

Also known as DEZ; RVER1; ChemR23; CHEMERINR

Gene ID: 1240 | Gene type: protein coding

About CMKLR1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,288,046-108,339,311 (from NCBI)

This gene has 6 transcripts (splice variants), 333 orthologues and 8 paralogues. Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues.

Summary

Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CMKLR1 Products(4)

mRNA	Protein	Name
NM_001142343.2	NP_001135815.1	chemerin-like receptor 1 isoform a
NM_001142344.2	NP_001135816.1	chemerin-like receptor 1 isoform a
NM_001142345.2	NP_001135817.1	chemerin-like receptor 1 isoform a
NM_004072.3	NP_004063.1	chemerin-like receptor 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adipokinetic hormone binding	IDA IDA: Inferred from direct assay	27716822	GOA
enables adipokinetic hormone receptor activity	IDA IDA: Inferred from direct assay	27716822	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14530373	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14530373	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	14530373	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15753205	GOA
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	19443732	GOA
involved in regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	14530373	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14530373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chemerin-like receptor 1

G-protein coupled receptor ChemR23

Related Diseases

Diseases

Alias

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Cardiovascular Syphilis

Syphilis, Cardiovascular

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic	Familial Hepatic Adenoma
Familial Liver Cell Adenomas	Liver Cell Adenomas, Familial
Hepatic Adenomas Familial	HEPAF
Ha	Hepatocellular Adenomas
Hepatocellular Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138097	α-NETA		≥98.0%	Unkown
HY-P1844A	Chemerin-9 (149-157) (TFA)		98.22%	Unkown
HY-156460	CMKLR1 antagonist 1	Antagonist	99.44%	Unkown
HY-P1844	Chemerin-9 (149-157)		/	Unkown
HY-RS02860	CMKLR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CMKLR1	VGNC	VGNC:60999
Macaca mulatta	CMKLR1	VGNC	VGNC:99920
Bos taurus	CMKLR1	VGNC	VGNC:52753
Canis familiaris	CMKLR1	VGNC	VGNC:39378
Rattus norvegicus	CMKLR1	RGD	RGD:69359
Mus musculus	CMKLR1	MGD	MGI:109603
Others	CMKLR1	NCBI

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