MSI2 - musashi RNA binding protein 2 Gene

Homo sapiens

Also known as MSI2H

Gene ID: 124540 | Gene type: protein coding

About MSI2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,255,851-57,701,581 (from NCBI)

This gene has 31 transcripts (splice variants), 261 orthologues, 36 paralogues and is associated with 66 phenotypes. Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues.

Summary

This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain Cancer cells. [provided by RefSeq, Apr 2016]

MSI2 Products(4)

mRNA	Protein	Name
NM_001322250.2	NP_001309179.1	RNA-binding protein Musashi homolog 2 isoform c
NM_001322251.2	NP_001309180.1	RNA-binding protein Musashi homolog 2 isoform d
NM_138962.4	NP_620412.1	RNA-binding protein Musashi homolog 2 isoform a
NM_170721.2	NP_733839.1	RNA-binding protein Musashi homolog 2 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	30367664	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSI2 Protein Structure

RRM_1

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein Musashi homolog 2

musashi homolog 2

MSI2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSI2	Q96DH6	CACNA1C	Homo sapiens	Q13936	Anti Bait CoIP	37207277
Intra	MSI2	Q96DH6	TIMM10B	Homo sapiens	Q9Y5J6	Anti Tag CoIP	33961781
Intra	MSI2	Q96DH6	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	MSI2	Q96DH6	MSI2	Homo sapiens	Q96DH6	AFM	30367664
Intra	MSI2	Q96DH6	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	MSI2	Q96DH6	HNRNPH2	Homo sapiens	P55795	Y2H Prey Pooling	25416956
Intra	MSI2	Q96DH6	MSI2	Homo sapiens	Q96DH6	Comigration in SDS	30367664
Intra	MSI2	Q96DH6	MSI2	Homo sapiens	Q96DH6	Confocal	30367664
Intra	MSI2	Q96DH6	MSI2	Homo sapiens	Q96DH6	IF	30367664
Intra	MSI2	Q96DH6	HNRNPH2	Homo sapiens	P55795	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Pineal Region Germinoma

Pineal Germinoma

B-Cell Adult Acute Lymphocytic Leukemia

Adult B Acute Lymphoblastic Leukemia	Adult B Acute Lymphoblastic Leukaemia
Adult B-Cell Acute Lymphoblastic Leukaemia	Adult B-Cell Acute Lymphoblastic Leukemia
Adult B-Cell Lymphocytic Leukaemia	Adult B-Cell Lymphocytic Leukemia
Adult B-Lymphoblastic Leukaemia	Adult B-Lymphoblastic Leukemia
B-Cell Adult Acute Lymphocytic Leukaemia	B-Cell Adult Acute Lymphoblastic Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08715	MSI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MSI2	MGD	MGI:1923876
Rattus norvegicus	MSI2	RGD	RGD:1560397
Macaca mulatta	MSI2	VGNC	VGNC:74793
Bos taurus	MSI2	VGNC	VGNC:107272
Others	MSI2	NCBI

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