Ccr6 - chemokine (C-C motif) receptor 6 Gene

Mus musculus

Also known as CCR-6; KY411; Cmkbr6; CC-CKR-6

Gene ID: 12458 | Gene type: protein coding

About Ccr6

Chromosome 17: 8,454,875-8,475,973 forward strand.GRCm39:CM001010.3

This gene has 9 transcripts (splice variants), 299 orthologues, 25 paralogues and is associated with 58 phenotypes. Biased expression in spleen adult (RPKM 9.8), mammary gland adult (RPKM 4.1) and 5 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in several processes, including immune system development; leukocyte migration; and regulation of cell motility. Located in external side of plasma membrane; sperm plasma membrane; and sperm principal piece. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and retina. Orthologous to human CCR6 (C-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Ccr6 Products(7)

mRNA	Protein	Name
NM_001190335.1	NP_001177264.1	C-C chemokine receptor type 6 isoform A
NM_001190334.1	NP_001177263.1	C-C chemokine receptor type 6 isoform A
NM_001190336.1	NP_001177265.1	C-C chemokine receptor type 6 isoform A
NM_001190333.1	NP_001177262.1	C-C chemokine receptor type 6 isoform A
NM_009835.4	NP_033965.1	C-C chemokine receptor type 6 isoform A
NM_001190338.1	NP_001177267.1	C-C chemokine receptor type 6 isoform B
NM_001190337.1	NP_001177266.1	C-C chemokine receptor type 6 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-C chemokine binding	IDA IDA: Inferred from direct assay	20068036	MGI
enables C-C chemokine receptor activity	IDA IDA: Inferred from direct assay	20068036	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9862452	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DN2 thymocyte differentiation	IMP IMP: Inferred from mutant phenotype	24638065	MGI
involved in DN3 thymocyte differentiation	IMP IMP: Inferred from mutant phenotype	24638065	MGI
involved in T cell migration	IDA IDA: Inferred from direct assay	24638065	MGI
involved in chemotaxis	IDA IDA: Inferred from direct assay	20068036	MGI
involved in isotype switching to IgA isotypes	IMP IMP: Inferred from mutant phenotype	27174992	MGI
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	19050256	MGI
involved in lymphocyte migration	IMP IMP: Inferred from mutant phenotype	27174992	MGI
involved in positive regulation of flagellated sperm motility involved in capacitation	IDA IDA: Inferred from direct assay	23765988	MGI
involved in regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	19050256	MGI
NOT involved in regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	19050256	MGI
involved in thymocyte migration	IDA IDA: Inferred from direct assay	24638065	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	23620790	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23034280	MGI
located in sperm flagellum	IDA IDA: Inferred from direct assay	23765988	MGI
located in sperm plasma membrane	IDA IDA: Inferred from direct assay	23765988	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	23765988	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr6 Protein Structure

7tmA_CCR6

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 6

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148531	PF-07054894	Inhibitor	99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151435	CCR6 antagonist 1	Antagonist	99.30%	Unkown
HY-112701	CCR6 inhibitor 1	Inhibitor	99.60%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr6	NCBI	NCBI:1235

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