2. Gene
  3. Cd22 - CD22 antigen Gene

Cd22 - CD22 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lyb8; Lyb-8; A530093D23

Gene ID: 12483 | Gene type: protein coding

About Cd22

Summary

Enables CD4 receptor binding activity; protein Phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd22 Products(2)

mRNA Protein Name
NM_001043317.2 NP_001036782.1 B-cell receptor CD22 precursor
NM_009845.3 NP_033975.3 B-cell receptor CD22 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CD4 receptor binding IPI
IPI: Inferred from physical interaction
12115612 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9890995 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12115612 MGI
enables sialic acid binding IPI
IPI: Inferred from physical interaction
12115612 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in negative regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in regulation of immune response IGI
IGI: Inferred from genetic interaction
20200274 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15095367 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8418208 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
15095367 MGI
located in plasma membrane IPI
IPI: Inferred from physical interaction
11606382 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell receptor CD22

B-lymphocyte cell adhesion molecule

BL-CAM

T-cell surface antigen Leu-14

sialic acid-binding Ig-like lectin 2

siglec-2

Recombinant Cd22 Proteins

Cat. No. Product Name Accession Purity
HY-P72474 Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His) AAA02562.1 (S22-R702) ≥95%
HY-P73646 Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc) BAE33829 (R19-R708) ≥95%
HY-P72474A Siglec-2/CD22 Protein, Mouse (HEK293, His) P35329-1 (S22-P702) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99264 Inotuzumab Inhibitor ≥95.0% Phase 4
HY-P99289 Epratuzumab 99.46% Phase 3
HY-P99034 Moxetumomab Inhibitor 95.00% Phase 3
HY-P990781 Suciraslimab 97.42% Phase 3
HY-P99230 Pinatuzumab Inhibitor 96.88% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141602 Pinatuzumab vedotin Inhibitor / Unkown
HY-146081 CD22 ligand-1 / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990930 Mozistobart / Unkown
HY-P99464 Bectumomab / Unkown
HY-P990759 Rezetamig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd22 NCBI NCBI:933
Macaca fascicularis Cd22 NCBI NCBI:102130968
Rattus norvegicus Cd22 NCBI NCBI:308501
Macaca mulatta Cd22 NCBI NCBI:106994739