2. Gene
  3. Cd44 - CD44 antigen Gene

Cd44 - CD44 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ly-24; Pgp-1; HERMES

Gene ID: 12505 | Gene type: protein coding

About Cd44

Summary

Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate Cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd44 Products(6)

mRNA Protein Name
NM_001039150.1 NP_001034239.1 CD44 antigen isoform b precursor
NM_001039151.1 NP_001034240.1 CD44 antigen isoform c precursor
NM_001177785.1 NP_001171256.1 CD44 antigen isoform d precursor
NM_001177786.1 NP_001171257.1 CD44 antigen isoform e precursor
NM_001177787.1 NP_001171258.1 CD44 antigen isoform f precursor
NM_009851.2 NP_033981.2 CD44 antigen isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cargo receptor activity IDA
IDA: Inferred from direct assay
1703543 MGI
enables cargo receptor activity IMP
IMP: Inferred from mutant phenotype
26528478 MGI
contributes to cytokine binding IDA
IDA: Inferred from direct assay
18056708 MGI
contributes to cytokine receptor activity IDA
IDA: Inferred from direct assay
17045821 MGI
enables hyaluronic acid binding IMP
IMP: Inferred from mutant phenotype
10926769 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7535771 MGI
enables type II transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
25065622 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
9374396 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
10926769 MGI
involved in hyaluronan catabolic process IDA
IDA: Inferred from direct assay
26528478 MGI
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
26528478 MGI
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17045821 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IDA
IDA: Inferred from direct assay
18056708 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17045821 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
9847236 MGI
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
26528478 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
26528478 MGI
acts upstream of or within wound healing involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
11935029 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10027409 MGI
located in cell surface IDA
IDA: Inferred from direct assay
9324354 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7538697 MGI
part of macrophage migration inhibitory factor receptor complex IDA
IDA: Inferred from direct assay
17045821 MGI
located in microvillus IDA
IDA: Inferred from direct assay
9472040 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9374396 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD44 antigen

ECMR-III

GP90 lymphocyte homing/adhesion receptor

HUTCH-I

PGP-I

extracellular matrix receptor III

hermes antigen

hyaluronate receptor

lymphocyte antigen 24

phagocytic glycoprotein 1

phagocytic glycoprotein I

Recombinant Cd44 Proteins

Cat. No. Product Name Accession Purity
HY-P74291 CD44 Protein, Mouse (HEK293, His) NP_001034240.1 (Q25-T224) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd44 NCBI NCBI:960
Macaca fascicularis Cd44 NCBI NCBI:101867504