CALR3 - calreticulin 3 Gene

Homo sapiens

Also known as CRT2; CT93; CMH19

Gene ID: 125972 | Gene type: protein coding

About CALR3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,479,061-16,496,167 (from NCBI)

This gene has 3 transcripts (splice variants), 117 orthologues, 3 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 33.9).

Summary

The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]

CALR3 Products(1)

mRNA	Protein	Name
NM_145046.5	NP_659483.2	calreticulin-3 precursor

CALR3 Protein Structure

Calreticulin

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

calreticulin-3

calreticulin-2

Recombinant CALR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7712	Calreticulin-3/CALR3 Protein, Human	Q96L12 (T20-L384)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 14

Hypertrophic Cardiomyopathy 14	CMH14
Cardiomyopathy, Hypertrophic, 14	Cardiomyopathy Familial Hypertrophic 14
Cardiomyopathy, Familial Hypertrophic 14	Cardiomyopathy, Hypertrophic, Familial, Type 14

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Pulmonary Adenocarcinoma In Situ

Bronchioalveolar Carcinoma

Lung Carcinoma In Situ

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01848	CALR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CALR3	VGNC	VGNC:38675
Macaca mulatta	CALR3	VGNC	VGNC:108487
Rattus norvegicus	CALR3	RGD	RGD:1309243
Mus musculus	CALR3	MGD	MGI:1920566
Felis catus	CALR3	VGNC	VGNC:69364
Bos taurus	CALR3	VGNC	VGNC:26716
Others	CALR3	NCBI

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