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  3. Calreticulin-3/CALR3 Protein, Human

Calreticulin-3/CALR3 Protein, Human

Cat. No.: HY-P7712
Handling Instructions

Calreticulin-3/CALR3 Protein, Human is a recombinant human Calreticulin-3 expressed in E. coli. Calreticulin (CRT) is a highly conserved chaperone-like lectin that regulates Ca2+ homeostasis and participates in protein quality control in the endoplasmic reticulum (ER).

For research use only. We do not sell to patients.

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Description

Calreticulin-3/CALR3 Protein, Human is a recombinant human Calreticulin-3 expressed in E. coli. Calreticulin (CRT) is a highly conserved chaperone-like lectin that regulates Ca2+ homeostasis and participates in protein quality control in the endoplasmic reticulum (ER)[1].

Background

The C-terminal domain of CRT3, which is rich in basic residues, is essential for retaining bri1-9 in the ER. CRT1 and CRT2, similar to the mammalian CRT1, have an acidic C-terminal domain and are co-expressed with known ER chaperones and folding catalysts, whereas CRT3 has a C-terminal domain enriched with basic residues such as histidine (His or H), arginine (Arg or R) and lysine (Lys or K) and is co-expressed with genes involved in plant stress responses[1].

Species

Human

Source

E. coli

Tag

Tag Free

Accession

Q96L12 (T20-L384)

Gene ID
Molecular Construction
N-term
CALR3 (T20-L384)
Accession # Q96L12
C-term
Synonyms
rHuCalreticulin-3; Calreticulin-3; calreticulin-2; calsperin; CALR3; CRT2
AA Sequence

TVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL

Molecular Weight

Approximately 42.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
References

Calreticulin-3/CALR3 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Calreticulin-3/CALR3 Protein, Human
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HY-P7712
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