TMIGD2 - transmembrane and immunoglobulin domain containing 2 Gene

Homo sapiens

Also known as CD28H; IGPR1; IGPR-1

Gene ID: 126259 | Gene type: protein coding

About TMIGD2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,292,227-4,302,389 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.5) and 14 other tissues.

Summary

Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TMIGD2 Products(4)

mRNA	Protein	Name
NM_001169126.2	NP_001162597.1	transmembrane and immunoglobulin domain-containing protein 2 isoform 2 precursor
NM_001308232.2	NP_001295161.1	transmembrane and immunoglobulin domain-containing protein 2 isoform 3
NM_001395549.1	NP_001382478.1	transmembrane and immunoglobulin domain-containing protein 2 isoform 4 precursor
NM_144615.3	NP_653216.2	transmembrane and immunoglobulin domain-containing protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	23784006	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23784006	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell costimulation	IDA IDA: Inferred from direct assay	23784006	GOA
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	23784006	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	22419821	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	23784006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMIGD2 Protein Structure

Ig_2

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

transmembrane and immunoglobulin domain-containing protein 2

CD28 homolog

Recombinant TMIGD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71370	TMIGD2 Protein, Human (HEK293, His)	Q96BF3-1 (L23-G150)	≥95%
HY-P77249	TMIGD2 Protein, Human (HEK293, Fc)	Q96BF3-1/NP_653216.2 (L23-G150)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14757	TMIGD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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