Chek1 - checkpoint kinase 1 Gene

Mus musculus

Also known as Chk1; rad27

Gene ID: 12649 | Gene type: protein coding

About Chek1

Chromosome 9: 36,619,778-36,638,361 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 178 orthologues and is associated with 10 phenotypes. Biased expression in CNS E11.5 (RPKM 8.), liver E14 (RPKM 5.6) and 9 other tissues.

Summary

Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 Products(4)

mRNA	Protein	Name
NM_001410206.1	NP_001397135.1	serine/threonine-protein kinase Chk1 isoform 3
NM_001410205.1	NP_001397134.1	serine/threonine-protein kinase Chk1 isoform 2
NM_007691.6	NP_031717.2	serine/threonine-protein kinase Chk1 isoform 1
NM_001410207.1	NP_001397136.1	serine/threonine-protein kinase Chk1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3T11 kinase activity	IDA IDA: Inferred from direct assay	18243098	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15364958	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	15364958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	12529385	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	10859164	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	11790307	MGI
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	18243098	MGI
acts upstream of or within DNA repair	IDA IDA: Inferred from direct assay	15364958	MGI
acts upstream of or within G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	10859164	MGI
acts upstream of or within apoptotic process involved in development	IMP IMP: Inferred from mutant phenotype	10859163	MGI
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	18243098	MGI
acts upstream of or within inner cell mass cell proliferation	IMP IMP: Inferred from mutant phenotype	10859163	MGI
acts upstream of or within mitotic cell cycle checkpoint signaling	IMP IMP: Inferred from mutant phenotype	10859163	MGI
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	18243098	MGI
acts upstream of or within nucleus organization	IMP IMP: Inferred from mutant phenotype	10859163	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15364958	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21737879	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	21737879	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	18243098	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11555636	MGI
located in replication fork	IDA IDA: Inferred from direct assay	15364958	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek1 Protein Structure

STKc_Chk1

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Chk1

CHK1 checkpoint homolog	checkpoint kinase 1 homolog
rad27 homolog

Recombinant Chek1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74253	Chk1 Protein, Mouse (sf9, His-GST)	O35280 (M1-T476)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1		/	Unkown
HY-RS02616	CHEK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02617	Chek1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02618	Chek1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chek1	NCBI	NCBI:1111

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