2. Gene
  3. Chek1 - checkpoint kinase 1 Gene

Chek1 - checkpoint kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Chk1; rad27

Gene ID: 12649 | Gene type: protein coding

About Chek1

Chromosome 9: 36,619,778-36,638,361 reverse strand.GRCm39:CM001002.3

This gene has 8 transcripts (splice variants), 178 orthologues and is associated with 10 phenotypes. Biased expression in CNS E11.5 (RPKM 8.), liver E14 (RPKM 5.6) and 9 other tissues.

Summary

Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 Products(4)

mRNA Protein Name
NM_001410206.1 NP_001397135.1 serine/threonine-protein kinase Chk1 isoform 3
NM_001410205.1 NP_001397134.1 serine/threonine-protein kinase Chk1 isoform 2
NM_007691.6 NP_031717.2 serine/threonine-protein kinase Chk1 isoform 1
NM_001410207.1 NP_001397136.1 serine/threonine-protein kinase Chk1 isoform 1

Chek1 Protein Structure

STKc_Chk1

STKc_Chk1: cd14069 (6 - 264)

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  • 476 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk1

CHK1 checkpoint homolog

checkpoint kinase 1 homolog

rad27 homolog

Recombinant Chek1 Proteins

Cat. No. Product Name Accession Purity
HY-P74253 Chk1 Protein, Mouse (sf9, His-GST) O35280 (M1-T476) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148065 FMF-06-098-1 / Unkown
HY-RS02616 CHEK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02617 Chek1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02618 Chek1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek1 NCBI NCBI:1111