2. Gene
  3. ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

ADH4 - alcohol dehydrogenase 4 (class II), pi polypeptide Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADH-2; HEL-S-4

Gene ID: 127 | Gene type: protein coding

About ADH4

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,123,658-99,144,297 (from NCBI)

This gene has 11 transcripts (splice variants), 346 orthologues and 17 paralogues. Restricted expression toward liver (RPKM 940.8).

Summary

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this Enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

ADH4 Products(3)

mRNA Protein Name
NM_000670.5 NP_000661.2 all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 2
NM_001306171.2 NP_001293100.1 all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1
NM_001306172.2 NP_001293101.1 all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform 1

ADH4 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (35 - 165)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (208 - 327)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

all-trans-retinol dehydrogenase [NAD(+)] ADH4

alcohol dehydrogenase class II pi chain

Related Diseases

Diseases Alias
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
Cluster Headache

Headache, Cluster
Hypocalciuric Hypercalcemia, Familial, Type Ii

HHC2

Familial Hypocalciuric Hypercalcemia 2

Fbh2

Familial Hypocalciuric Hypercalcemia Type 2

Hypocalciuric Hypercalcemia, Type Ii

Fhh Type 2

Familial Benign Hypercalcemia, Type Ii

Hypercalcemia, Familial Benign, Type Ii

Hypocalciuric Hypercalcemia Type Ii

Familial Benign Hypercalcemia, Type 2

Hypercalcemia, Familial Benign Type 2

Hypocalciuric Hypercalcemia, Familial, Type 2

Hypocalciuric Hypercalcemia, Familial 2

Familial Benign Hypercalcemia Type Ii

Hypocalciuric Hypercalcemia-2
Hypocalciuric Hypercalcemia, Familial, Type I

HHC1

Familial Hypocalciuric Hypercalcemia 1

Fhh1

Familial Benign Hypercalcemia 1

Fbh1

Hypocalciuric Hypercalcemia, Type I

Fhh Type 1

Hhc

Fhh

Hypercalcemia, Familial Benign

Hypocalciuric Hypercalcemia Type I

Familial Hypocalciuric Hypercalcemia Type 1

Hypocalciuric Hypercalcemia, Familial, Type 1

Familial Hypocalciuric Hypercalcemia Type I

Familial Benign Hypercalcemia Type 1

Hypercalcemia, Familial Benign Type 1

Hypocalciuric Hypercalcemia, Familial 1

Familial Benign Hypocalciuric Hypercalcemia 1

Fbhh1
Substance Dependence
Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia

Fbh

Fbhh

Fhh

Familial Benign Hypocalciuric Hypercalcemia

Hypocalciuric Hypercalcemia, Familial, Type 1
Headache

Headache Disorder
Hypocalcemia, Autosomal Dominant 1

Autosomal Dominant Hypocalcemia

Autosomal Dominant Hypocalcemia 1

HYPOC1

Hypocalcemia, Autosomal Dominant

Hypercalciuric Hypocalcemia

Hypocalcemia, Autosomal Dominant, With Bartter Syndrome

Familial Hypocalcemia

Hypocalcemia, Familial

Hypoc

Adh

Autosomal Dominant Hypoparathyroidism

Familial Hypercalciuric Hypocalcemia

Ad Hypocalcemia

Autosomal Dominant Hypocalcemia With Bartter Syndrome

Hypoparathyroidism - Autosomal Dominant

Hypocalcemia
Familial Isolated Hypoparathyroidism

Fih
Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00369 ADH4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADH4 RGD RGD:71028
Mus musculus ADH4 MGD MGI:1349472