2. Gene
  3. LYPLAL1 - lysophospholipase like 1 Gene

LYPLAL1 - lysophospholipase like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Q96AV0

Gene ID: 127018 | Gene type: protein coding

About LYPLAL1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:219,173,878-219,445,496 (from NCBI)

This gene has 12 transcripts (splice variants), 173 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 3.2), heart (RPKM 2.4) and 25 other tissues.

Summary

Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in protein depalmitoylation. Predicted to act upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LYPLAL1 Products(7)

mRNA Protein Name
NM_001300769.2 NP_001287698.1 lysophospholipase-like protein 1 isoform b
NM_001300770.2 NP_001287699.1 lysophospholipase-like protein 1 isoform c
NM_001300771.2 NP_001287700.1 lysophospholipase-like protein 1 isoform d
NM_001300772.2 NP_001287701.1 lysophospholipase-like protein 1 isoform d
NM_001350628.2 NP_001337557.1 lysophospholipase-like protein 1 isoform e
NM_001350629.2 NP_001337558.1 lysophospholipase-like protein 1 isoform f
NM_138794.5 NP_620149.2 lysophospholipase-like protein 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables hydrolase activity, acting on ester bonds IDA
IDA: Inferred from direct assay
22052940 GOA
NOT enables lipase activity IDA
IDA: Inferred from direct assay
22052940 GOA
enables palmitoyl-(protein) hydrolase activity IDA
IDA: Inferred from direct assay
37802025 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: Inferred from direct assay
37802025 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYPLAL1 Protein Structure

Abhydrolase_2

Abhydrolase_2: Phospholipase/Carboxylesterase (12 - 225)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

lysophospholipase-like protein 1

LYPLAL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LYPLAL1 Q5VWZ2 CT55 Homo sapiens Q8WUE5
Y2H Prey Pooling
32296183
Intra
LYPLAL1 Q5VWZ2 CT55 Homo sapiens Q8WUE5
Validated Y2H
32296183
Intra
LYPLAL1 Q5VWZ2 CT55 Homo sapiens Q8WUE5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124700 LYPLAL1-IN-1 Inhibitor ≥99.0% Unkown
HY-147049 PAL-4 Activator / Unkown
HY-RS07923 LYPLAL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LYPLAL1 MGD MGI:2385115
Macaca mulatta LYPLAL1 VGNC VGNC:74319
Felis catus LYPLAL1 VGNC VGNC:63344
Bos taurus LYPLAL1 VGNC VGNC:31107
Rattus norvegicus LYPLAL1 RGD RGD:1311195
Canis familiaris LYPLAL1 VGNC VGNC:42892