Plk3 - polo like kinase 3 Gene

Mus musculus

Also known as Cnk; Fnk; PRK; PLK-3

Gene ID: 12795 | Gene type: protein coding

About Plk3

Chromosome 4: 116,985,852-116,991,160 reverse strand.GRCm39:CM000997.3

This gene has 3 transcripts (splice variants), 203 orthologues, 4 paralogues and is associated with 11 phenotypes. Ubiquitous expression in colon adult (RPKM 33.3), stomach adult (RPKM 16.7) and 24 other tissues.

Summary

This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Plk3 Products(2)

mRNA	Protein	Name
NM_001313916.1	NP_001300845.1	serine/threonine-protein kinase PLK3 isoform 2
NM_013807.3	NP_038835.2	serine/threonine-protein kinase PLK3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20940307	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20940307	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21376736	MGI
involved in mitotic G1/S transition checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21376736	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20940307	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	22854038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk3 Protein Structure

STKc_PLK3

POLO_box_1

POLO_box_2

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PLK3

FGF-inducible kinase

cytokine-inducible serine/threonine-protein kinase

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137	Volasertib	Inhibitor	99.41%	Yes
HY-12137A	Volasertib trihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50698	BI 2536	Inhibitor	99.95%	Phase 2
HY-147298	Plogosertib	Inhibitor	99.95%	Phase 2
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.19%	Phase 1
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10197	Wortmannin	Inhibitor	99.86%	Unkown
HY-100789	ON1231320	Inhibitor	99.24%	Unkown
HY-11003	GW843682X	Inhibitor	99.89%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.56%	Unkown
HY-15158	SBE13 Hydrochloride	Inhibitor	99.66%	Unkown
HY-12134	Poloxin	Inhibitor	98.01%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-15158A	SBE13	Inhibitor	/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plk3	NCBI	NCBI:1263

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