VSTM2L - V-set and transmembrane domain containing 2 like Gene

Homo sapiens

Also known as C20orf102; dJ1118M15.2

Gene ID: 128434 | Gene type: protein coding

About VSTM2L

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,903,127-37,945,350 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 3 paralogues. Biased expression in brain (RPKM 19.4), gall bladder (RPKM 10.9) and 7 other tissues.

Summary

Predicted to enable cell-cell adhesion mediator activity. Involved in negative regulation of neuron apoptotic process. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

VSTM2L Products(1)

mRNA	Protein	Name
NM_080607.3	NP_542174.1	V-set and transmembrane domain-containing protein 2-like protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21393573	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21393573	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	21393573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSTM2L Protein Structure

V-set

0
100
204 a.a.

Protein Preferred Names

Protein Names

V-set and transmembrane domain-containing protein 2-like protein

VSTM2L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VSTM2L	Q96N03	CCM2	Homo sapiens	Q9BSQ5	Lumier	25814554
Intra	VSTM2L	Q96N03	CCM2	Homo sapiens	Q9BSQ5	Validated Y2H	25814554
Intra	VSTM2L	Q96N03	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bietti Crystalline Corneoretinal Dystrophy

BCD	Bietti Crystalline Dystrophy
Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy	Bietti Crystalline Retinopathy
Bietti'S Crystalline Dystrophy	Crystalline Retinopathy
Dystrophy, Corneoretinal, Crystalline, Bietti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15716	VSTM2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VSTM2L	MGD	MGI:2685537
Canis familiaris	VSTM2L	VGNC	VGNC:48311
Felis catus	VSTM2L	VGNC	VGNC:81257
Bos taurus	VSTM2L	VGNC	VGNC:36844
Rattus norvegicus	VSTM2L	RGD	RGD:1305725
Macaca mulatta	VSTM2L	VGNC	VGNC:97840

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