2. Gene
  3. Cr2 - complement receptor 2 Gene

Cr2 - complement receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cr1; C3DR; CD21; CD35; Cr-1; Cr-2

Gene ID: 12902 | Gene type: protein coding

About Cr2

Summary

Enables Complement Receptor activity. Acts upstream of or within with a negative effect on complement activation, alternative pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cr2 Products(2)

mRNA Protein Name
NM_001368765.1 NP_001355694.1 complement receptor type 2 isoform 1 precursor
NM_007758.3 NP_031784.1 complement receptor type 2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables complement receptor activity IMP
IMP: Inferred from mutant phenotype
11728339 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11728339 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
11728339 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cellular response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within negative effect complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within immunoglobulin mediated immune response IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
19828624 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8041705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement receptor type 2

complement C3d receptor

complement receptor type 1

expressed in B lymphocytes

Recombinant Cr2 Proteins

Cat. No. Product Name Accession Purity
HY-P77602 CD21 Protein, Mouse (HEK293, His) P19070 (I12-W963) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-NP137 NP-PE (Phycoerythrin) / Unkown
HY-N12760 Lobophorin CR-2 / Unkown
HY-RS03133 CR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cr2 NCBI NCBI:1380
Macaca fascicularis Cr2 NCBI NCBI:102145559
Macaca mulatta Cr2 NCBI NCBI:714202