2. Gene
  3. Crh - corticotropin releasing hormone Gene

Crh - corticotropin releasing hormone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CRF; Gm1347

Gene ID: 12918 | Gene type: protein coding

About Crh

Summary

This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]

Crh Products(1)

mRNA Protein Name
NM_205769.3 NP_991338.1 corticoliberin preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adrenal gland development IMP
IMP: Inferred from mutant phenotype
10861000 MGI
acts upstream of or within glucocorticoid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10861000 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15159534 MGI
acts upstream of or within locomotory exploration behavior IGI
IGI: Inferred from genetic interaction
17908177 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10861000 MGI
Cellular Component GO Annotation Evidence Reference Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
32094113 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

corticoliberin

corticotropin releasing factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103377 Antalarmin hydrochloride Antagonist 99.87% Unkown
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 99.71% Unkown
HY-P1245 Neuropeptide SF (human) Activator 99.53% Unkown
HY-P1245A Neuropeptide SF (human) acetate Activator / Unkown
HY-P3130 Stresscopin-related peptide (human) / Unkown
HY-P3683 a-Helical Corticotropin Releasing Factor (12-41) Inhibitor / Unkown
HY-P3684 [DPro5] Corticotropin Releasing Factor, human, rat Agonist / Unkown
HY-P3687 [Tyr0] Corticotropin Releasing Factor, ovine Agonist / Unkown
HY-RS03166 CRH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crh NCBI NCBI:1392
Macaca fascicularis Crh NCBI NCBI:101925337