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  5. [Tyr0] Corticotropin Releasing Factor, ovine

[Tyr0] Corticotropin Releasing Factor, ovine 

Cat. No.: HY-P3687
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[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.

For research use only. We do not sell to patients.

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[Tyr0] Corticotropin Releasing Factor, ovine Chemical Structure

[Tyr0] Corticotropin Releasing Factor, ovine Chemical Structure

CAS No. : 83930-34-1

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[Tyr0] Corticotropin Releasing Factor, ovine Related Antibodies

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Description

[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2].

In Vitro

[Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Tyr0] Corticotropin Releasing Factor, ovine Related Antibodies
In Vivo

[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young adult male cynomolgus monkeys (4.0-6.9 kg)[1]
Dosage: 10 mL/h for 198 pg/min or 225 pg/min
Administration: Continuous infusions intravenous; collected every 60 min during 5-7 hr
Result: Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).
Molecular Weight

4833.48

Formula

C214H348N60O65S
CAS No.
Sequence Shortening

Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
References
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[Tyr0] Corticotropin Releasing Factor, ovine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Tyr0] Corticotropin Releasing Factor, ovine83930-34-1Othershypothalamic hormoneadrenocorticotrophic hormoneACTHCRFCRHInhibitorinhibitorinhibit

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