AADAC - arylacetamide deacetylase Gene

Homo sapiens

Also known as DAC; CES5A1

Gene ID: 13 | Gene type: protein coding

About AADAC

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,814,116-151,828,488 (from NCBI)

This gene has 2 transcripts (splice variants), 214 orthologues and 5 paralogues. Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues.

Summary

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

AADAC Products(1)

mRNA	Protein	Name
NM_001086.3	NP_001077.2	arylacetamide deacetylase

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables deacetylase activity	IDA IDA: Inferred from direct assay	9665742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables serine hydrolase activity	IDA IDA: Inferred from direct assay	17936933	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10318829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AADAC Protein Structure

Abhydrolase_3

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

arylacetamide deacetylase

arylacetamide deacetylase (esterase)

AADAC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	AADAC	P22760	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AADAC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72067	AADAC Protein, Human (His-SUMO)	P22760 (P24-L399)	≥95%

Related Diseases

Diseases

Alias

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Tic Disorder

Tics	Behavioral Tic

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00017	AADAC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AADAC	VGNC	VGNC:81172
Mus musculus	AADAC	MGD	MGI:1915008
Canis familiaris	AADAC	VGNC	VGNC:37404
Rattus norvegicus	AADAC	RGD	RGD:631440
Others	AADAC	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.