Cst7 - cystatin F (leukocystatin) Gene

Mus musculus

Also known as Cmap

Gene ID: 13011 | Gene type: protein coding

About Cst7

Summary

Enables cysteine-type endopeptidase inhibitor activity. Involved in negative regulation of peptidase activity. Acts upstream of or within inhibition of cysteine-type endopeptidase activity; negative regulation of microglial cell activation; and positive regulation of myelination. Located in several cellular components, including Golgi apparatus; late endosome; and lysosome. Is expressed in several structures, including early conceptus and female reproductive system. Orthologous to human CST7 (Cystatin F). [provided by Alliance of Genome Resources, Apr 2022]

Cst7 Products(1)

mRNA	Protein	Name
NM_009977.3	NP_034107.2	cystatin-F precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	28251676	MGI
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	18256700	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within inhibition of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	28251676	MGI
acts upstream of or within negative regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	28251676	MGI
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	18256700	MGI
acts upstream of or within positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	28251676	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18256700	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	28251676	MGI
located in cytoplasmic vesicle	IMP IMP: Inferred from mutant phenotype	15212960	MGI
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	15212960	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	28178353	MGI
located in late endosome	IMP IMP: Inferred from mutant phenotype	15212960	MGI
located in lysosome	IMP IMP: Inferred from mutant phenotype	15212960	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cystatin-F

cystatin-7

cystatin-like metastasis-associated protein

Recombinant Cst7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7853	Cystatin F/CST7 Protein, Mouse (HEK293, His)	O89098 (A19-Q144)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03268	CST7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cst7	NCBI	NCBI:8530

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