CST7 - cystatin F Gene

Homo sapiens

Also known as CMAP

Gene ID: 8530 | Gene type: protein coding

About CST7

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:24,949,269-24,959,928 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 11 paralogues. Biased expression in bone marrow (RPKM 321.5), spleen (RPKM 27.1) and 1 other tissue.

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human Cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]

CST7 Products(1)

mRNA	Protein	Name
NM_003650.4	NP_003641.3	cystatin-F precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	15752368	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18256700	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	15212960	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	15752368	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18256700	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12423348	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15212960	GOA
located in endosome	IDA IDA: Inferred from direct assay	15752368	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	12423348	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15752368	GOA
located in multivesicular body	IDA IDA: Inferred from direct assay	22365146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CST7 Protein Structure

Cystatin

0
100
145 a.a.

Protein Preferred Names

Protein Names

cystatin-F

cystatin-7

CST7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CST7	O76096	CTSC	Homo sapiens	P53634	Anti Tag CoIP	18256700

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CST7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7851	Cystatin F/CST7 Protein, Human (HEK293, His)	O76096 (G20-H145)	≥95%

Related Diseases

Diseases

Alias

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease	Papillon-Lefèvre Syndrome
PLS	Keratosis Palmoplantaris With Periodontopathia
PALS	Papillon Lefevre Syndrome
Keratosis Palmoplantar-Periodontopathy Syndrome	Papillon-Lefvre Syndrome
Hyperkeratosis Palmoplantaris With Periodontosis	Keratoris Palmoplantaris With Periodontopathia
Keratosis Palmoplantar - Periodontopathy	Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction
Palmoplantar Keratoderma With Periodontosis	Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03268	CST7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CST7	MGD	MGI:1298217
Bos taurus	CST7	VGNC	VGNC:27777
Rattus norvegicus	CST7	RGD	RGD:1309154
Felis catus	CST7	VGNC	VGNC:61237
Canis familiaris	CST7	VGNC	VGNC:39679
Macaca mulatta	CST7	VGNC	VGNC:71532
Others	CST7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.