Ctsd - cathepsin D Gene

Mus musculus

Also known as CD; CatD

Gene ID: 13033 | Gene type: protein coding

About Ctsd

Chromosome 7: 141,929,648-141,941,775 reverse strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 42 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 1266.1), mammary gland adult (RPKM 682.4) and 23 other tissues.

Summary

Enables aspartic-type endopeptidase activity. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and optic nerve. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (Cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]

Ctsd Products(1)

mRNA	Protein	Name
NM_009983.3	NP_034113.1	cathepsin D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	19293336	MGI
enables aspartic-type peptidase activity	IMP IMP: Inferred from mutant phenotype	16997486	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	26467158	MGI
enables hydrolase activity	IDA IDA: Inferred from direct assay	19710420	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	15588329	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28453791	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	15452145	MGI
NOT involved in epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	17500053	MGI
involved in insulin catabolic process	IDA IDA: Inferred from direct assay	27703010	MGI
involved in insulin receptor recycling	IDA IDA: Inferred from direct assay	27703010	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endosome lumen	IDA IDA: Inferred from direct assay	27703010	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	19710420	MGI
located in lysosome	IDA IDA: Inferred from direct assay	9034150	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsd Protein Structure

A1_Propeptide

Cathepsin_D2

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

cathepsin D

Recombinant Ctsd Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7749	Cathepsin D Protein, Mouse (HEK293, His)	P18242 (I21-L410)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	99.29%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03328	CTSD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03329	Ctsd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P2750	Cathepsin D		/	Unkown
HY-RS03330	Ctsd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsd	NCBI	NCBI:1509

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